Strategic Business Manager Commercial Operations

• Work Schedule
• Standard (Mon-Fri)
• Environmental Conditions
• Office
• Job Description

• Location:

• East Coast, Remote Thermo Fisher Scientific's Large Molecule Business Unit (LMBU) is a global Contract Development and Manufacturing Organization (CDMO) supporting customers in bringing biologic therapies to patients.

The Sr. Manager - Commercial Systems and Strategy is a key leader within the Commercial Operations Office, responsible for designing, operating, and continuously improving the systems, planning processes, and capability frameworks that enable disciplined commercial execution across the BU. This role serves as a hands-on owner and integrator of enterprise planning, demand planning, and commercial capability development. The Sr. Manager ensures commercial inputs are structured, credible, and actionable—and that teams are trained, aligned, and enabled to execute consistently at scale.

• How will you make an impact?
• You will translate strategy into execution by ensuring the Large Molecule BU has clear planning mechanisms, integrated demand signals, and well-trained commercial teams.

Your work will improve forecast reliability, strengthen alignment between commercial and operations teams, and increase adoption of standard tools and processes. Success in this role is measured by planning quality, system effectiveness, and organizational capability, not individual deal outcomes.

• What you will do:
• Enterprise Planning (LRP, AOP & Strategic Cycles)
• Support and execute the commercial components of Long Range Planning (LRP), Annual Operating Plan (AOP), and strategic planning cycles
• Develop and maintain planning templates, assumptions, calendars, and governance mechanisms
• Consolidate and validate commercial inputs to ensure consistency, accuracy, and alignment with BU strategy
• Partner with Finance, Sales, and Business Management to translate strategy into executable plans and targets
• Prepare planning outputs, analyses, and insights for leadership reviews
• SIOP & Demand Planning Enablement
• Own commercial inputs into SIOP and demand planning processes
• Structure demand signals to ensure they are credible, timely, and aligned with operational planning needs
• Partner with Supply Chain, Operations, and Finance to improve alignment between demand forecasts and capacity planning
• Identify gaps, risks, and variability in demand signals and recommend mitigation actions
• Support continuous improvement of demand planning tools, cadence, and governance
• Commercial Systems & Data Enablement
• Support the commercial systems roadmap, ensuring tools effectively enable planning, forecasting, and performance tracking
• Serve as a functional expert for commercial planning and forecasting systems
• Partner with IT and enterprise teams to improve system usability, data quality, and integration
• Develop standard reports, dashboards, and analytics to support decision-making
• Training, Learning & Capability Development
• Design and deploy role-based training for commercial systems, planning processes, and governance standards
• Develop onboarding materials, standard work documentation, and learning pathways for commercial-facing roles
• Partner with functional leaders to assess capability gaps and prioritize development initiatives
• Promote consistent adoption of tools, processes, and best practices through structured learning and reinforcement Continuous Improvement & Change Support
• Identify opportunities to simplify, standardize, and improve commercial planning and execution processes
• Support change management for new systems, processes, and planning approaches
• Track adoption, effectiveness, and benefits realization for commercial initiatives
• Cross-Functional Collaboration
• Act as a day-to-day integrator across Commercial Operations, Business
• Management, Sales, Finance, and Operations
• Ensure clear communication of expectations, timelines, and standards across planning and execution activities
• Escalate risks and misalignment early with data-driven insights and recommendations
• How you will get here:
• Education
• Bachelor's degree in business, finance, engineering, or scientific discipline required
• MBA or advanced business degree preferred
• Experience
• 8-10 years of experience in commercial operations, business management, finance, supply chain, or enterprise planning roles
• Experience supporting or leading planning cycles (LRP, AOP) and/or SIOP processes
• Experience in pharmaceutical, biotechnology, or CDMO environments preferred
• Demonstrated experience working in matrixed, cross-functional organizations Knowledge, Skills, Abilities
• Strong understanding of enterprise planning, demand planning, and commercial operations
• Systems-oriented thinker with comfort working in planning and forecasting tools
• Highly organized with strong attention to detail and follow-through
• Analytical mindset with ability to translate data into insights
• Effective communicator able to influence without formal authority
• Comfortable operating between strategy and execution
• Passion for building scalable processes, tools, and organizational capability
• Compensation and Benefits
• The salary range estimated for this position based in Missouri is $118,100.

00-$177,200.00. This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes: + A choice of national medical and dental plans, and a national vision plan, including health incentive programs + Employee assistance and family support programs, including commuter benefits and tuition reimbursement + At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy + Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan + Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewardsThermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.