Director of Project Management Office, Cell Therapy Technical Operations

At AstraZeneca's, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most sophisticated diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Position Summary The Director of Project Management Office, Cell Therapy Technical Operations is a highly strategic leadership role responsible for establishing, digitizing, and leading the Operations branch of the centralized Cell Therapy Technical Operations (CTTO) PMO. This leader will set up the PMO's ways of working across CTTO with the ultimate vision of building a PM-enabled, self-sufficient organization. Reporting into the CMC Portfolio Strategy Cell Therapy organization, this role will oversee high-value Technical and Operational Projects while simultaneously establishing the standard project management framework, governance, tools, and best practices to be utilized across all tiers of the CTTO projects portfolio. By leveraging artificial intelligence and digital automation aligned with AstraZeneca's 2030 ambition, this role will empower technical leaders to manage projects independently, utilizing dedicated PMO resources primarily for complex initiation and planning phases. This position is based in Gaithersburg, MD.

Responsibilities Strategic Project Execution:

Directly manage or oversee the execution of complex, highly cross-functional above-site Projects ensuring on-time and on-budget delivery.

Portfolio Visibility & Tracking:

Develop, implement, and maintain a centralized, real-time portfolio dashboard capturing all active projects across the CTTO organization, ensuring full transparency of organizational demand, resources, and strategic alignment.

PMO Vision & Self-Sufficiency:

Design and embed standard project management ways of working across CTTO to foster a PM-enabled, self-sufficient organization. Empower functional Subject Matter Experts (SMEs) and leaders to act as independent Project Leads, requiring dedicated PMO support for critical lifecycle steps like project initiation and complex planning.

Digital Transformation & AI Integration:

Develop, maintain, and continuously improve the PMO by leveraging cutting-edge digital solutions and artificial intelligence in alignment with AstraZeneca's 2030 ambition. Partner directly with IT to design, test, and implement custom AI tools and automation strategies that streamline project management workflows.

Standardization & Best Practices:

Act as the authoritative voice for project management methodology within CTTO. Design, deploy, and govern standardized, highly automated tools (e.g., Project Charters, RAID logs, unified RAG dashboards) to ensure uniform, efficient ways of working across all project tiers.

Governance:

Partner with the CTTO Leadership Team acting as the Project Review Committee (PRC). Facilitate governance meetings to drive data-backed, Go/No-Go decisions, manage capacity forecasting, prioritize resource allocation, and rapidly resolve escalated project risks.

Cross-Functional Community of Practice:

Foster a collaborative relationship with the internal CMC PM team to build a unified Community of Practice. Lead outward-facing networking by engaging with enterprise PM communities outside of CTDO, influencing broader AstraZeneca standards, and integrating industry-leading digital practices back into the organization.

Supervisory Responsibilities Team Leadership:

Provides direct line management to a targeted team of Cell Therapy Project Managers and external contractors deployed for peak portfolio demand or specialized planning phases.

Talent Cultivation:

Cultivates talent through coaching, professional development, and succession planning. Ensures the team builds the necessary matrix leadership skills, digital fluency, and strategic execution capabilities required to drive complex business objectives.

Escalation Management:

Leads formal issue escalation and resolution in partnership with the matrix team, sponsors, and the Project Review Committee (PRC).

Essential Requirements:

Education:

Bachelor's degree in a Life Sciences, Engineering, or relevant technical field required. Master's degree or MBA is highly preferred.

Experience:

10+ years of experience in the pharmaceutical, biotech, or Cell Therapy industry, with at least 8+ years specifically in project, program, or portfolio management.

Leadership:

Proven experience managing direct reports and leading PMOs or shared-service project teams within a complex, highly matrixed environment.

Technical Acumen:

Deep operational understanding of cell therapy supply chain, vein-to-vein logistics, network capacity, and cGMP/regulatory requirements.

Methodologies & Tools:

Advanced proficiency in portfolio management software (e.g., Smartsheet, MS Project, Agile). Active PMP (Project Management Professional) certification is required, with Lean Six Sigma highly desired.

Communication & Influencing Skills:

Outstanding written, interpersonal, and executive-level presentation skills. Must possess the ability to distill complex operational data into clear, compelling narratives to effectively influence senior leadership, drive alignment, and foster collaboration across diverse stakeholder groups.

Change Management:

drive change management across organizational levels, and reset cultural expectations regarding project governance and resource allocation.

Digital & AI Fluency:

Tech-savvy and avid practitioner of digital automation and AI tools highly preferred. Proven experience working alongside IT departments to develop and implement digital or AI-driven solutions specifically for operational or project portfolio management is a plus.

Travel:

Willingness to travel occasionally for business purposes. When we put unexpected teams in the same room, we unleash bold thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. The annual base pay for this position ranges from $149,806 - $224,708 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Are you ready to bring new insights and fresh thinking to the table? Fantastic! We have one seat available, and we hope it's yours. Apply today. AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Date Posted 18-May-2026 Closing Date 07-Jun-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We're curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We're driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you'll do work that has the potential to change your life and improve countless others. And, together with your team, you'll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.