Supply Chain Manager

Job Title:

Clinical Supply Chain Manager (Contractor) Job Description This full-time Clinical Supply Chain Manager (Contractor) role leads end-to-end clinical supply chain activities for global development programs across a diverse portfolio of small molecule and biologic drug candidates. You will own the clinical supply strategy from study start-up through closeout, overseeing planning, forecasting, packaging, labeling, inventory management, distribution, returns, and reconciliation to ensure seamless delivery of investigational medicinal products to patients worldwide. Partnering closely with Clinical Operations, CMC, Quality, Regulatory, Project Management, and external partners, you will design and execute agile, scalable supply solutions that optimize speed, quality, and patient-centricity. The role requires strong operational leadership, systems thinking, and a continuous improvement mindset in a fast-paced, highly outsourced environment. Responsibilities Lead end-to-end clinical supply strategy and execution for global clinical programs from study start-up through closeout. Develop agile and scalable supply strategies that adapt to patient enrollment variability, program priorities, and evolving operational requirements. Proactively identify supply risks and develop mitigation strategies using data, scenario planning, and risk-based approaches to maintain supply continuity. Translate clinical protocols into robust demand forecasts and supply plans, balancing long-range program planning with hands-on study execution. Own and manage all clinical supply activities, including packaging, labeling, inventory management, distribution, depot set-up, returns, and reconciliation. Optimize inventory levels to maximize product utilization and minimize waste due to expiry or retest dates. Ensure seamless global distribution of investigational medicinal products through integrated supply planning and execution frameworks. Serve as the subject matter expert for drug supply within

IRT/RTSM

systems, including implementation, configuration, and ongoing optimization. Drive adoption of automation and AI-enabled tools to streamline workflows, improve operational efficiency, and enhance supply visibility. Support the implementation and future scaling of planning and supply chain technologies to enable data-driven decision-making. Lead operational governance with CDMOs, CROs, depots, and logistics providers to ensure high-quality execution against forecasts and timelines. Establish and track performance metrics, conducting data-driven business reviews with external partners to improve service delivery and accountability. Ensure clinical supply operations comply with GMP, GCP, ICH, FDA, EMA, and other applicable global regulatory frameworks. Partner with Quality to manage deviations, CAPAs, change controls, and product complaints related to clinical supplies. Apply risk-based methodologies to balance quality and compliance requirements with operational agility and speed. Drive alignment across Clinical Operations, CMC, Quality, Regulatory, Project Management, and external partners on supply strategies, plans, and execution. Communicate supply risks, constraints, and mitigation strategies clearly and proactively through actionable reporting and regular updates. Influence cross-functional decision-making through open communication, strategic thinking, and collaborative problem solving. Oversee CDMOs to ensure clinical supply continuity, timely manufacturing, and execution against agreed forecasts and study needs. Identify issues and risks early across CMC, manufacturing, and clinical teams, and lead cross-functional discussions to drive timely decisions. Own internal management of temperature excursions and product complaints, coordinating with Quality and external partners as needed. Manage and maintain accurate inventory and forecasting datasets using advanced Excel capabilities and related tools. Forecast drug supply and demand using Excel (including pivot tables, formulas, and data analytics) to support study planning and decision-making. Work effectively within Google Workspace and other collaboration tools to manage documents, data, and cross-functional communication. Support comparator sourcing and management for global clinical trials, ensuring adequate supply and compliance with regulatory requirements. Contribute to building and refining clinical supply chain infrastructure, processes, and best practices as one of the earliest members of the team. Essential Skills Bachelor's degree in Life Sciences, Business, Supply Chain, or a related discipline. 8+ years of clinical supply chain experience in biotech or pharmaceutical settings, with the majority focused on clinical supply chain. Demonstrated experience managing clinical supply chains for both small molecule and biologic products across all phases of clinical development. Proven ability to translate clinical protocols into accurate demand forecasts and comprehensive supply plans. Strong understanding of end-to-end clinical supply chain processes, including planning, packaging, labeling, distribution, depot setup, returns, and reconciliation. Hands-on experience managing external vendors on the sponsor side, including CDMOs and other supply chain partners. Experience overseeing CDMOs to ensure supply continuity and execution against clinical forecasts. Strong knowledge of supply forecasting methodologies, IRT/RTSM systems, and inventory strategy. Experience with

IRT/RTSM

systems such as IQVIA, Medidata, or similar platforms, with platform-agnostic, transferable expertise. Demonstrated ability to manage internal ownership of temperature excursions and product complaints. Advanced Excel skills, including pivot tables, formulas, and data analytics for forecasting and inventory management. Ability to manage inventory and forecasting datasets efficiently and accurately. Experience ensuring compliance with GMP, GCP, ICH, FDA, EMA, and other global regulatory requirements in a clinical supply context. Proven experience in comparator sourcing and management for global clinical trials. Experience working with rare disease, oncology, biologics, and complex clinical trial designs. Strong project and program management skills within clinical supply chain operations. Excellent communication skills to drive alignment, escalation, transparency, and decision-making across cross-functional teams. Demonstrated ability to identify risks early and drive supply decisions in collaboration with CMC, manufacturing, and clinical teams. Additional Skills & Qualifications Advanced degree in a relevant field is preferred but not required. Experience in broader supply chain, purchasing, procurement, customer service, or contract negotiation is beneficial. Comfort working in a highly outsourced operating model where CDMOs handle manufacturing, logistics, and distribution, and the internal team focuses on oversight and escalation. Exposure to or interest in planning tools implementation and other scalable supply chain technologies. Experience working within Google Workspace or similar collaboration platforms. Openness to AI and automation tools, with enthusiasm for leveraging technology to improve processes. Agile, proactive, and comfortable operating in an environment with limited infrastructure and evolving processes. High ownership mentality with a strong sense of accountability for outcomes. Ability to build strong relationships and collaborate effectively across internal teams and external partners. Passionate, curious, and trainable mindset with a focus on continuous learning and improvement. Work Environment This is a full-time role, typically around 40 hours per week, based primarily on-site in a collaborative office and laboratory-adjacent environment. The position generally requires being on-site most of the week, with flexibility for a portion of time to be remote for highly qualified candidates, depending on business needs. You will work as the second member of a growing clinical supply chain team that sits within the CMC function and reports into the broader CMC organization. The operating model is fully outsourced, with CDMOs managing manufacturing, logistics, and distribution, while the internal team focuses on strategic oversight, governance, and issue escalation. Exceptions such as temperature excursions and product complaints are handled in-house, providing exposure to critical quality and compliance activities. The environment heavily leverages digital tools, including advanced Excel, Google Workspace, and emerging AI and automation technologies, with potential future exposure to planning tool implementation. The culture emphasizes ownership, agility, cross-functional collaboration, and building infrastructure and processes from the ground up. On-site amenities include provided lunches, supporting an engaging and team-oriented workplace. Job Type & Location This is a Contract position based out of South San Francisco, CA. Pay and Benefits The pay range for this position is $65.00 - $85.00/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a hybrid position in South San Francisco,CA.

Application Deadline This position is anticipated to close on Jun 3, 2026. About Actalent Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law. If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

San Francisco Fair Chance Ordinance:

Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector:

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.