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Assistant Research Professor Brain Tumor Immunology and Therapeutic Delivery
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City of Hope
Duarte, CA (In Person)
$140,649 Salary, Full-Time
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Job Description
Assistant Research Professor - Brain Tumor Immunology and Therapeutic Delivery City of Hope - 3.6 Duarte, CA Job Details Full-time $62.20 - $73.04 an hour 22 hours ago Qualifications Research grant funding Scientific publications CRISPR-Cas9 Mentoring Translational research Full Job Description Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The laboratory of Dr. Behnam Badie has an opportunity to join his team as an Assistant Research Professor. Dr. Badie is a physician‑scientist and neurosurgeon who leads a highly translational research program focused on immunology, neuroinflammation, and therapeutic innovation for malignant brain tumors. As a successful candidate, you will: Investigate the role of myeloid-derived cells, neuroinflammation, and tumor-immune interactions in malignant brain tumor progression and therapeutic resistance. Identify therapeutic opportunities through Receptor for Advanced Glycation End products (RAGE) pathway targeting, gene regulation, and evaluation of novel small-molecule RAGE inhibitors in preclinical models. Develop and optimize cell-penetrating oligonucleotides, including siRNA and antisense oligonucleotides (ASOs), to modulate gene expression in tumor cells and myeloid populations. Design, validate, and advance nanoparticle-based delivery systems for siRNA, ASOs, gene-editing tools, and small molecules. Engineer delivery strategies that enhance blood-brain barrier penetration, tumor specificity, cellular uptake, and immune compatibility. Evaluate pharmacokinetics, biodistribution, efficacy, and toxicity in relevant in vitro and in vivo brain tumor models. Apply CRISPR-based gene editing, gene regulation, functional genomics, transcriptomics, and immunophenotyping approaches to study tumor progression and immune response. Develop translational therapeutic strategies, including nucleic-acid-based immunotherapies, immune-cell-based drug delivery approaches, CAR T-cell collaborations, and bioengineering/device development efforts.