Assistant Research Professor

Appointment Type:

Scientist Track Faculty Department:

IUSM -

Microbiology & Immunology Campus:

IU School of Medicine Indianapolis Position Summary Position Summary The Indiana University School of Medicine is seeking applications for a full-time Assistant Research Professor to support research in the laboratory of Dr. Randy R. Brutkiewicz , Professor of Microbiology & Immunology and Full Member of the Stark Neuroscience Research Institute. The laboratory investigates innate immune mechanisms regulating antigen presentation, with a specific emphasis on the

MR1/MAIT

cell axis and its role in Alzheimer's disease . Recent work from the group has demonstrated MR1-mediated antigen presentation by microglia, astrocytes and neurons, and identified contributions of the

MR1/MAIT

cell axis to neuroinflammation and Alzheimer's disease progression.

The successful candidate will contribute to ongoing federally funded research programs and develop independent lines of investigation aligned with the laboratory's focus. Primary Responsibilities Conduct research on MR1-mediated antigen presentation and MAIT cell biology in neurodegenerative disease models. Design, execute, and analyze experiments related to innate immune regulation in Alzheimer's disease. Contribute to manuscript preparation, grant applications, and scientific presentations. Collaborate with internal and external investigators within immunology and neuroscience. Provide mentorship to trainees and technical staff. Maintain compliance with institutional and federal research regulations. IU School of Medicine is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana. Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the nation's largest concentrations of health sciences companies. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city and surrounding suburbs enjoy leading educational systems and top-ranked universities paired with a diverse population. Indianapolis International Airport is a top-ranked international airport that has been named "Best Airport in North America" by Airports Council International for many years. For additional information on life in

Indy:

https://faculty.medicine.iu.edu/relocation Faculty Affairs and Professional Development | IU School of Medicine Basic Qualifications Required Qualifications Ph.D. in Immunology, Neuroscience, Microbiology, or a related discipline. Minimum of 5 years of research experience in innate immunity within the context of neurodegenerative and other CNS disorders. Demonstrated expertise in cellular immunology, antigen presentation, or neuroimmune interactions. Evidence of productivity through peer-reviewed publications. Ability to work independently and collaboratively in a multidisciplinary research environment. Department Contact for Questions Gerri Herron HR Coordinator geherron@iu.edu Additional Qualifications Preferred Qualifications Experience with mouse models of Alzheimer's disease (e.g., 5XFAD). Background in

MR1/MAIT

cell biology and other innate immune axes. Experience with neuroinflammation assays, imaging, or single-cell/spatial technologies. Prior work involving CD1d, NKT cells, or innate-like T cell subsets.

Expected Start Date:

04/13/2026 Posting Number IUSM-02364-2026