Downstream Process Scientist

Downstream Process Scientist at Cube Hub Inc. Downstream Process Scientist at Cube Hub Inc. in Oceanside, California Posted in 3 days ago.

Type:

full-time

Job Description:

Job Title:

Senior Research Associate I - Downstream Process Development (Protein Purification) Job Summary We are seeking a highly motivated Senior Research Associate I to support process development activities focused on biologics purification . This role involves hands-on laboratory work, execution of purification experiments, data analysis, and collaboration with cross-functional teams to support process optimization, characterization, and technology transfer to GMP manufacturing. Key Responsibilities Plan and execute laboratory experiments to support downstream process development and project goals Perform protein purification using techniques such as chromatography, tangential flow filtration (UF/DF), and filtration Analyze and interpret experimental data, ensuring data quality and identifying anomalies Contribute to process optimization, characterization, and scale-up activities Collaborate with cross-functional teams including Process Development, Analytical, and Manufacturing Support technology transfer activities from development to GMP manufacturing Assist in troubleshooting purification processes and recommending improvements Document experimental results and contribute to technical reports, validation documents, and regulatory filings Present data, results, and conclusions in team meetings Maintain compliance with cGMP and safety standards , including handling potent compounds upon training Required Qualifications BS degree in Chemical Engineering, Biochemical Engineering, Biochemistry, Chemistry, or related field with 2+ years of relevant experience , OR MS degree in a relevant scientific discipline Preferred Qualifications Hands-on experience in biologics purification / downstream process development Experience with tangential flow filtration (TFF/UFDF), chromatography, and filtration techniques Familiarity with purification of monoclonal antibodies (mAbs) or other biologics (e.g., bispecifics, fusion proteins, ADCs) Exposure to analytical techniques such as

SEC-HPLC, CE

(reducing/non-reducing), or HCP testing Knowledge of cGMP environments, process scale-up, and technology transfer Understanding of downstream unit operations including centrifugation, filtration, chromatography, and virus clearance Skills & Competencies Strong experimental design and problem-solving skills Ability to analyze and interpret complex scientific data Excellent technical writing and documentation skills Effective communication and collaboration in a team-oriented environment Self-motivated, detail-oriented, and eager to learn Work Environment On-site laboratory role Requires adherence to safety protocols and handling of potent compounds Nice to Have Experience with multiple expression systems (mammalian and microbial) Exposure to regulatory documentation and process validation