Job Description
Job Title:
Senior Scientist - Process Modelling Location:
Framingham, MA About the Job The global CMC(Chemistry Manufacturing and Control)functionis responsible forprocess development activities in R D, designingappropriate controlstrategytodeliverprocesses ofoptimumproduct quality, supplying material for clinicaltrialsandensuring robust transfer of the process to our commercial organization. The CMC organization is undergoing a substantial digitaltransformation that is transformingour experimental workflows. The digitalization ofthe labactivities provides automated access to experimental data,contextualizationand centralizationof the data accessibleto scientists acrossallCMC sites and functions. As experimental data becomes readily available, the data consumption strategy is takinga central rolein the department, with a strong focus ondata preparation, data flow anddata consumption, feedingapplicationsdeveloped in-houseand commercial software used across CMCfordata visualization, data modeling andadvanced data analytics. In this role, you will be based in the process modelling team within the CMC Data Science group. Our team provides process modeling and data analytics support for cell line selection, cell culture process development, process scale-up and technology transfer across microbial hosts, mammalian hosts, and gene therapies. Join the engine of Sanofis mission where deep immunoscience meets bold, AI-powered research. In R D, youll drive breakthroughs that could turn the impossible into possible for millions. About Sanofi:
Were an R D-driven, AI-powered biopharma company committed to improving peoples lives and delivering compelling growth. Our deep understanding of the immune system and innovative pipeline enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve peoples lives. Main Responsibilities:
Develop, calibrate, and validate bioreactor dynamic models to simulate, optimize, and control recombinant protein production and product quality attributes. Transfer and deploy bioreactor models in a commercial manufacturing environment to support process monitoring and forecasting ( digital shadows ) and/or real-time bioreactor optimization and control ( digital twins ). Work as part of matrix project teams with cell-culture development, process development, analytical, automation, and data science teams across R D and manufacturing. Communicate model assumptions, uncertainty, limitations, and process interpretation to technical and non-technical stakeholders Maintain reproducible computational workflows using appropriate coding, documentation, version control, and data-management practices. Act as a change agent to support the implementation of process modeling in established cell culture process development workflows. Document progress against deliverables with rigorous scientific communication via technical presentations, reports and, when appropriate, scientific publications. About You Basic Qualifications Education PhD in Chemical Engineering, Biochemical Engineering, Process Systems Engineering, Bioengineering, Biomedical Engineering, or related engineering or scientific discipline OR Master's degree in any of the above fields Experience PhD holders: Minimum 1 year of relevant experience (academic, research assistantship, or industry experience will be considered) Master's holders: Minimum 4 years of relevant industry or research experience Demonstrated experience developing dynamic models of bioreactor or cell culture processes Proficiency in at least one scientific computing language: Python, MATLAB, Julia, or R Preferred Qualifications Experience developing dynamic mechanistic models using ordinary differential equations (ODEs), kinetic rate laws, mass balances, parameter estimation, and model validation Strong understanding of mammalian cell culture process development , including fed-batch and/or perfusion bioreactor operation Proven track record of developing and deploying bioreactor digital twins , process models, or advanced monitoring tools in an industrial biopharmaceutical environment Understanding of bioreactor engineering principles : oxygen transfer, mixing, mass transfer, CO stripping, kLa, shear, scale-up and scale-down models Experience with perfusion bioreactor modeling : cell retention, bleed strategies, media exchange, residence time, productivity, and steady-state operation Experience with multivariate statistical process monitoring techniques such as PCA or PLS for early fault detection Familiarity with soft sensors, state estimation, Kalman filtering , moving-horizon estimation, or real-time process monitoring and model predictive control Track record of peer-reviewed publications in process modeling/simulation for upstream biopharmaceutical processes Prior experience working with international/global teams across multiple time zones and locations Why Choose Us Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether its through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks gender-neutral parental leave. Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. Help improve the lives of millions of people globally by making drug development quicker and more effective. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SA #LI-SA #LI-Onsite #vhd All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
