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Downstream Process Development Engineer, Large Scale Protein Purification (MA)

Job

ThermoFisher Scientific

Framingham, MA (In Person)

$116,500 Salary, Full-Time

Posted 6 weeks ago (Updated 6 weeks ago) • Actively hiring

Expires 5/27/2026

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Job Description

  • Work Schedule
  • Standard (Mon-Fri)
  • Environmental Conditions
  • Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
  • Job Description
  • Thermo Fisher Scientific is seeking a
  • Downstream Process Development Engineer
  • to support development, scale-up, and customer enablement of downstream purification processes using our industry-leading single-use and hybrid purification platforms. This role is highly hands-on, customer-facing, and focused on large-scale chromatography execution, troubleshooting, and technology transfer.
  • Location:
  • This is an onsite position in Plainville, Massachusetts. Residency within commuting distance is required. No relocation assistance will be provided.
  • What You'll Do
  • + Develop and execute downstream purification processes across capture, intermediate, and polishing steps. + Perform
  • hands-on large-scale protein purification
  • , including operation of chromatography columns
  • 30 cm to 60 cm ID
  • . + Pack, qualify, and troubleshoot large-scale chromatography columns, ensuring consistent performance across cycles. + Diagnose and resolve
  • pressure, flow distribution, and resin-related issues
  • , including column fouling, pressure excursions, and yield losses. + Make
  • real-time process adjustments during chromatography runs
  • based on system trends and performance data. + Operate and optimize
  • chromatography skids (single-use and/or stainless steel)
  • , including systems controlled via
  • DeltaV
  • . + Review
  • process trends, alarms, and historian data
  • to drive process understanding and improvement. + Generate high-quality technical data demonstrating robustness, scalability, and reproducibility. + Support
  • PD → pilot → manufacturing scale transitions
  • and participate in customer or internal tech transfer discussions. + Lead hands-on customer training, demonstrations, and technical workshops. + Collaborate cross-functionally with R D, automation, manufacturing, and commercial teams.
  • Required Qualifications
  • + B.S. in Chemical Engineering, Biochemistry, Biotechnology, or related field with
  • 5+ years
  • of relevant experience; + M.S. with
  • 3+ years
  • of relevant experience; + Ph.D. with relevant industry experience. +
  • Hands-on experience with protein purification using chromatography
  • , including capture, intermediate, and polishing steps. +
  • Direct experience operating large-scale chromatography columns (≥30 cm ID)
  • . + Experience packing and qualifying chromatography columns in development or pilot-scale environments. + Strong ability to
  • diagnose chromatography performance issues
  • , including pressure, flow, and resin behavior. + Solid
  • mechanical and fluid-flow intuition
  • for packed-bed chromatography. + Experience operating downstream single-use purification systems. + Demonstrated
  • end-to-end ownership of unit operations
  • , with accountability for execution and outcomes. + Strong planning, execution, and technical documentation skills.
  • Preferred Qualifications
  • + Experience operating chromatography columns
  • 45-60 cm ID
  • at pilot or manufacturing scale. + Hands-on experience with
  • resin lifetime studies, reuse strategies, and column performance trending across multiple cycles
  • . + Understanding of
  • resin selection tradeoffs
  • (binding capacity, pressure limitations, fouling risk). + Knowledge of
  • cleaning, sanitization, and storage practices
  • for chromatography resins and columns. + Experience operating
  • chromatography skids using DeltaV
  • , including navigation of batch phases and recipe logic. + Ability to collaborate with automation engineers on
  • phase logic optimization and troubleshooting
  • . + Familiarity with
  • electronic batch records (EBR) or MES interfaces
  • . + Understanding of
  • scale-dependent risks
  • , including flow distribution, pressure scaling, and residence time effects. + Experience translating small-scale learnings into
  • robust operating ranges
  • for pilot or manufacturing scale. + Experience supporting
  • customer-facing troubleshooting, training, or technology transfer
  • activities. + Demonstrated proactive identification of
  • process risks and continuous improvement opportunities
  • .
    • Physical Requirements
    • + Ability to work in a laboratory environment and handle light to moderate lifting (up to ~50 lbs) + Standing and walking for extended periods during experimental execution + Manual dexterity to operate laboratory equipment and instrumentation
    • Compensation and Benefits
    • The salary range estimated for this position based in Massachusetts is $96,000.
    00-$137,000.00. This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes: + A choice of national medical and dental plans, and a national vision plan, including health incentive programs + Employee assistance and family support programs, including commuter benefits and tuition reimbursement + At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy + Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan + Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewardsThermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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