Lyophilization Technician

First Job Previous Job 187 of 1,378 Next Job Last Job Share More Like This Salary Not Available Position range in Columbia, MO Metropolitan Statistical Area $43k - $63k Per Year Lyophilization Technician Horizon Analytical LLC

Occupation:

Installation, Maintenance, and Repair Workers, All Other

Location:

Columbia, MO - 65216 Positions available: 1 Job #: bad0adca

Source:

ZipRecruiter

Posted:

04/27/2026

Delivery Method:

ZipRecruiter

Web Site:

www.ziprecruiter.com

Job Type:

Full Time (30 Hours or More) Job Requirements and Properties Help for Job Requirements and Properties. Opens a new window. Work Onsite Full Time Schedule Full Time Job Description Help for Job Description. Opens a new window. Job DescriptionJob Description Horizon Analytical | Columbia, Missouri | Full-Time, On-Site About the Role Horizon Analytical is seeking a skilled Lyophilization Technician to join our pharmaceutical operations team. This role is central to the production of high-quality peptide formulations, with primary responsibility for executing freeze-drying cycles under strict aseptic conditions. The ideal candidate brings hands-on lyophilization experience, a rigorous attention to detail, and a strong foundation in sterile processing. Key Responsibilities

• Operate and maintain pharmaceutical-grade lyophilizers throughout all phases of the freeze-drying process, including freezing, primary drying, and secondary drying.
• Execute validated lyophilization cycles for peptide formulations while adhering to established Standard Operating Procedures.
• Perform aseptic filling, loading, and unloading of lyophilizers within ISO-classified cleanroom environments.
• Conduct routine equipment qualification checks, preventive maintenance, and troubleshooting in coordination with the engineering and QA teams.
• Document all batch activities in accordance with cGMP requirements, including batch records, deviation reports, and environmental monitoring logs.
• Support cycle development and optimization efforts for new peptide products in collaboration with formulation scientists.
• Participate in cleanroom gowning qualification, media fills, and environmental monitoring programs.
• Assist in investigation of deviations, OOS results, and CAPA implementation as needed. Required Qualifications
• Bachelor's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or a related scientific discipline.
• One to five years of direct lyophilization experience in a pharmaceutical, biotech, or compounding pharmacy setting.
• Demonstrated proficiency in aseptic technique, including gowning, material transfer, and sterile manipulations within ISO 5 and ISO 7 environments.
• Working knowledge of c

GMP, USP

797 and USP 800 compliance standards.

• Experience interpreting and executing batch records, SOPs, and validation protocols.
• Ability to lift up to 40 lbs and stand for extended periods during cleanroom shifts. Preferred Qualifications
• Master's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or a related scientific discipline.
• Prior experience with peptide formulation, fill-finish operations, or sterile injectable manufacturing.
• Familiarity with lyophilizer control systems from manufacturers such as SP Scientific, IMA, or Millrock.
• Experience with process analytical technology including manometric temperature measurement and residual moisture analysis.
• Understanding of stability testing, container closure integrity, and reconstitution behavior of lyophilized products.

What We Offer Competitive salary commensurate with experience, comprehensive health and dental benefits, paid time off, professional development support, and the opportunity to work on cutting-edge peptide programs in a growing pharmaceutical operation based in Columbia. To Apply Submit your resume and a brief cover letter outlining your lyophilization experience to Horizon Analytical's hiring team. Qualified candidates will be contacted for an initial screening interview. Horizon Analytical is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.