Protein Scientist, Downstream Process Development

We are looking for a talented scientist to lead the development, optimization, and scale-up of downstream purification processes for monoclonal antibodies and other biologics, from early development through clinical and commercial manufacturing. This role is responsible for designing robust, scalable, and regulatory-compliant purification processes, with a focus on translating lab-scale workflows into high-yield, cost-effective GMP manufacturing processes. The individual will serve as a technical leader across process development, tech transfer, and manufacturing.

Key Responsibilities:

Design, develop, and optimize downstream purification processes for monoclonal antibodies and other therapeutic and non-therapeutic proteins, including clarification, capture, intermediate, and polishing steps Lead scale-up activities from bench to pilot and commercial manufacturing, including process modeling and tech transfer to CDMOs. Author and review technical reports, development protocols, and regulatory documentation, in support of tech transfer Lead or support technology transfer to GMP manufacturing sites Collaborate with upstream, analytical, and quality teams to ensure process robustness and product quality Support process validation activities Evaluate and implement new purification technologies to improve efficiency, yield, and cost of goods Requirements 5+ years of industry experience in downstream process development for monoclonal antibodies or closely related biologics Ph.D. in biochemical engineering, chemical engineering, biochemistry, or related field; or equivalent industry experience Demonstrated experience scaling purification processes from bench scale to pilot and/or commercial manufacturing scale Deep expertise in core mAb purification unit operations: Protein A affinity chromatography Ion exchange (IEX), hydrophobic interaction chromatography (HIC) Viral inactivation and viral filtration Ultrafiltration/diafiltration (UF/DF) Expertise in chromatography process development and scale-up, including mass transfer and capacity studies, Design of Experiments (DoE) screening for performance optimization, as well as productivity and resin lifecycle modeling Hands-on experience with manufacturing-relevant equipment (ÄKTA process systems, large-scale columns, TFF systems) Demonstrable success in tech transfer to GMP manufacturing environments (internal or CDMO) Experience managing external partners (CDMOs) and overseeing manufacturing campaigns Experience overseeing manufacturing campaigns, including managing timelines, risk, and troubleshooting efforts to support tech transfer Appetite for fast-paced startup environment and teamwork

Benefits Compensation:

base salary is expected to be $130-170K depending on experience, with additional bonus compensation, equity compensation, and benefits.