Job Description
We're building a connected, end-to-end Enterprise AI engine - uniting data foundations, AI technology, process reinvention, and business-facing AI to accelerate results across the whole value chain. Success depends on being exceptional connectors: you'll actively leverage existing capabilities, celebrate and promote reuse, export breakthrough ideas across geographies and functions, and obsess over scaling impact rather than building in isolation. If you thrive in high-collaboration environments where your role is to turn complex, cross-functional problems into reusable, enterprise-wide capabilities - and where the measure of success is adoption and scale, not just innovation - you'll have the platform (and sponsorship) to make it real. About AISI AI Science & Innovation (AISI) sits at the centre of AstraZeneca's R D AI transformation. Our remit is to build, buy and deliver the AI models and agents that change pipeline outcomes, across discovery, translational science, biomarkers and clinical development. Role Overview AstraZeneca is building a world-class AI capability for Clinical Development within AISI to accelerate the design, conduct, and analysis of clinical trials across our Oncology and BioPharmaceuticals pipeline. We are hiring the Head of AI for Clinical Operations to lead the science and the team that turns AI promise into real-world operational improvements in how AstraZeneca runs its trials. This is one of the highest impact challenges in AI for healthcare. Trials run for years, span thousands of clinicians and patients across dozens of countries, and generate streams of noisy, heterogeneous, regulated data. The playbook for AI in this environment will be developed in the next two to three years. You will advance the science of AI for trial execution and bring better treatments to patients, faster, while adhering to the highest evidentiary, GxP, and patient safety standards. We're hiring someone who sees this high bar as the reason to come, not a reason to hesitate. The AI for Clinical Development function is being built from the ground up, and you'll help define how AstraZeneca does AI for clinical operations. Expect an outsized voice with regulators, scientific consortia, and external partners during the narrow window when the rules of the road for agentic
AI, AI/ML
governance, and AI in trial conduct are being written. We hire for learning agility and technical excellence. The strongest candidate is the person who learns fast, is comfortable with ambiguity, prototypes early, fails forward, and partners credibly across communities (ML, clinical, biostatistics, regulatory). We're seeking an engineer-leader with the leadership, technical depth, and curiosity to develop, adapt, and apply the most advanced methods in AI (e.g., agentic systems, multimodal foundation models, tool-use and orchestration, domain-specific evaluation environments) to clinical operations workflows, and who can sit across from clinical operations teams to translate their priorities into actionable, evaluable AI solutions. Above all, this is a role where the science matters. Every model you ship will eventually touch a trial, and a patient. That is the bar we hold ourselves to, and the bar we hire to. What you'll do Lead AstraZeneca's AI R D for clinical operations across Oncology and BioPharmaceuticals — turning AI into measurable cycle-time, quality, and patient-experience outcomes in live trials. Lead a team of AI researchers and engineers to deliver AI for trial planning, conduct, monitoring, and reporting across the trial lifecycle. Partner closely with Clinical Operations to design and implement a strategy for AI-enabled operations. Develop and deploy agentic systems for high-leverage trial workflows (e.g., AI-assisted protocol authoring, eligibility screening and patient-trial matching, site selection, AE and SAE detection, query and data-review acceleration, source data verification, risk-based monitoring decision support). Build the AI for Clinical Development team's reusable evaluation environments for clinical agents so that every system shipped has a defensible measurement story. Oversee the standardization and harmonization of multimodal data for clinical operations AI, including EHR, clinical trial management systems, eTMF. Partner with Regulatory teams to develop AI-enabled trial-conduct standards and evidence that meet GxP, GCP, data-integrity, and emerging AI/ML regulatory expectations. Work closely with the Heads of AI for Early and Late Clinical Development on AI hand-offs from design through conduct, and contribute to the team's unified, reusable, and end-to-end strategies for AI method development, evaluation, monitoring, and oversight. Contribute the AI scientific and methodological voice on regulatory engagement for AI in trial conduct (GCP, agentic systems, data integrity). Represent AstraZeneca externally in industry forums, scientific consortia, and peer-reviewed venues. Serve as a thought partner for AISI and AI for Clinical Development leadership. Recruit, mentor, and lead a team of approximately four AI scientists and engineers as a player-coach who is hands-on with code, models, and trial-execution workflows while building a high-performing team that keeps up-to-date with the latest advances in frontier AI models and agents. Essential for the role MD (or equivalent clinical degree), MD-PhD, or PhD in Computer Science, Machine Learning, Computational Biomedical Sciences, Biomedical Informatics, or a closely related computational discipline, with a strong, hands-on computational track record. Minimum 8 years of combined experience across AI/ML method development and clinical research, clinical operations, or clinical development delivery with demonstrated impact on research enablement or live clinical deployment. Current, hands-on computational expertise: peer-reviewed publications in top-tier conferences and/or journals and shipped code in clinical AI, agentic systems, clinical NLP, or related areas. Comfort writing code, reviewing model implementations, and reproducing results. Hands-on experience designing and deploying agentic systems and LLM-based workflows in real clinical or healthcare environments, including agent harness design, tool-use scaffolding, multi-step orchestration, and LLM post-training methods. Strong experience in generative and non-generative AI benchmarking and evaluation across clinical and/or biomedical settings, including the construction of domain-specific evaluation environments for tasks with noisy or underspecified ground truth. Deep familiarity with modern AI methods relevant to trial operations: large language models, agentic systems, clinical NLP, multimodal models, generative AI, interpretability and oversight, and human-in-the-loop workflow AI. Working knowledge of clinical operations and trial conduct and the GxP, GCP, data-integrity, and validation expectations that apply to AI in live trials. Demonstrated track record of translating AI methods into applications that inform clinical decisions or trial execution, including prospective evaluation, deployment, or live-trial use. Demonstrated scientific leadership:
mentoring scientists, leading multi-author projects, or running a small team. Excellent written and verbal communication, able to translate technical findings for clinical, regulatory, and executive audiences. Desirable for the role Direct industry experience in clinical operations, clinical trial technology, or digital trial delivery within a pharmaceutical, biotech, or CRO environment. Experience with deep-research, computer-use, or browsing benchmarks for clinical AI, and the construction of evaluation environments for them. Prior FDA, EMA, ICH, or other regulator engagement on AI in trial conduct, GCP for AI, data integrity standards for AI/ML, or evaluation and reporting standards for medical AI. First- or last-author publications at top ML venues (NeurIPS, ICML, ICLR, •CL) and/or top clinical and biomedical journals. Open-source contributions, workshop organisation, or standards-body participation. Office Working Requirements When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. The annual base pay for this position ranges from $ 203 213,60 - 304 820,40 Annual USD. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered include a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. #EA Date Posted 29-maj-2026 Closing Date 12-juni-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We're curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We're driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you'll do work that has the potential to change your life and improve countless others. And, together with your team, you'll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.
