Senior Medical Director Clinical Development Neuroscience

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC® Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC® targeted protein degraders, that are designed to harness the body's own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. Arvinas is currently progressing multiple investigational drugs through clinical development programs, including ARV-102, targeting LRRK2 for neurodegenerative diseases; ARV-806, targeting

KRAS G12D

for mutated cancers, including pancreatic, colorectal, and non-small cell lung cancers; ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle; and vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic

ER+/HER2

• breast cancer. On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant
• an investigational, orally bioavailable PROTAC estrogen receptor degrader
• for its use as a monotherapy in the treatment of adults with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2
• , ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy.

In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC® androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and mission

• to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We're really excited about the work we're doing inside and outside of Arvinas, and think you will be, too. But don't just take our word for it
• learn more about life at Arvinas and what employees have to say.

Arvinas is headquartered in New Haven, Connecticut. For more information about Arvinas, visit www.arvinas.com and connect on LinkedIn and X . Position Summary Arvinas is looking for an experienced Senior Medical Director with the passion and creativity to develop great medicines for neuromuscular and neurodegenerative diseases. The ideal candidate is a physician with experience in global drug development and filing, who is enthusiastic about applying their knowledge to improve the lives of patients with neurological diseases. This individual has excellent management and leadership capabilities and is motivated to participate in and lead an innovative drug development team. Reporting to the Executive Medical Director of Clinical Research, Neuroscience, the Senior Medical Director will be primarily responsible for the development, oversight, and execution of clinical research and development programs, including pivotal trials and filing activities. This position will serve as a key liaison between company and clinical investigators and establish credible relationships with opinion leaders, regulatory officials and other key stakeholders and partners. The successful candidate will be ready for a career defining experience and have the passion to drive several therapeutics for serious debilitating diseases to final approval. This role can be located at our headquarters in New Haven, CT or work with a hybrid or remote work arrangement from a location within the U.S. Principal Responsibilities Key responsibilities of this role include, but are not limited to: Partner with discovery and biology leadership and provide clinical input and guidance to develop the neuroscience corporate strategy. Design Phase

I/II/III

research trials targeting neurologic diseases, requiring expertise and stewardship in the areas of CNS/Neurology Monitor the safety of patients enrolled in clinical studies Provide medical and scientific input in review of clinical data, patient medical safety data, and laboratory values, maintaining an ongoing assessment of the safety profile, and efficacy data, as appropriate. Work closely with all functions of the organization and external partners to manage trial execution and investigators' engagement. Collaborate in developing global regulatory plans and play a key role in regulatory meetings in partnership with regulatory affairs. Identify, develop, and maintain relationships with external experts to better understand the candidate drug's effects and gain strategic insights to strengthen the program. Provide clinical assessments of potential in-licensing assets, identifying novel therapeutics opportunities as well as critical study design and execution challenges. Lead the interpretation and summary of clinical trial data, including the preparation of study reports, integrated summaries, and clinical portions of package inserts and other product labeling. Provide input on and review of various reports, applications, and publications Ensure consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations, and laws. Additional Responsibilities, including but not limited to: Participate in the selection of clinical investigators Provide guidance to study investigators Provide medical support to Clinical Operations in the oversight of contract research organizations Provide medical and scientific input on clinical data, patient medical safety data, and laboratory values, maintaining an ongoing assessment of the safety profile, and efficacy data, as appropriate. Contribute to the overall strategy for drug development Collaborate on the preparation and submission of IND, CTA, and NDA documents, and safety reports. Support the clinical aspects of interactions with regulatory agencies worldwide Participate in the planning, writing, and review of Clinical Study Reports, regulatory updates, and submissions. Analyze and interpret study data for abstracts or publication as required. Assist in the evaluation of scientific opportunities by contributing to due diligence activities, including critical assessment of clinical and translational data. Provide medical expertise to support corporate partnering and business development efforts, including active participation in partnership committees and cross-functional task groups. Collaborate with senior leadership and cross-functional teams to inform overall company strategy and contribute to the identification, evaluation, and in-licensing of new programs. Work with the financial group as needed to assist with the production of budgets and timelines for the clinical development team. Ensure that medical activities in clinical trials are conducted in compliance with Good Clinical Practice standards. Qualifications A minimum of 5 years (7+ years strongly preferred) of biotech/pharma experience in neurological disease clinical drug development Experience across multiple stages of clinical development, from IND to

NDA / BLA.

Global clinical development experience is required, and global filing experience is preferred. Technical (Medical and Scientific) experience evaluating targets/agents for in-licensing or internal development. Experience supervising physicians and/or scientific staff in a management or team leader capacity is highly desirable. Excellent interpersonal and public speaking skills are required for this high visibility position. Demonstrated ability to work in a matrix environment with cross-functional teams. Must be legally authorized to work in the US without the need for employer sponsorship now or at any time in the future. The duties of this role are generally conducted in a home office environment. Employees must be able, with or without accommodation, to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. Education M.D. or equivalent degree is required. Formal training in Neurology and professional board certification are highly preferred.

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Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.