Manufacturing Shift Manager

Manufacturing Shift Manager (Wednesday•Saturday, 7:00AM•5:30PM)•

Rockville, MD Summary:

The Manufacturing Shift Manager is accountable for execution on the direct manufacturing floor. Expectations of proficient use of cGxPs is required, as well as resource and workload management. Must be able and willing to work onsite shift days/hours of Wednesday-Saturday 0700-1730

Responsibilities:

Managing the operations pertaining to the production of cell therapy products Coaching, 1:1 meetings and support, leadership of staff Oversight of staff, including On the floor support expected 50%+ of time. Oversee and assist as required of successful execution of manufacturing batch records, work instructions and SOPs, with a focus 'right the first time' Provides technical instruction to the team and allocates administrative work where possible•assigning tasks to other manufacturing staff, leading activities on manufacturing floor, communicating to staff about product status at shift change, troubleshooting processing and equipment issues. Ownership and oversight of the Tier 2 cross-functional board and metrics, as well as participation and escalation to Tier 3 and cross-functional leaders to resolve issues seen within the manufacturing site. Execute procedural review and approval of documentation. Documentation of all activities to meet cGMP requirements. Review (batch records, SOPs, Logbooks) for completeness, clarity, accuracy and submit edits to documents for revision as needed. Create, Own, and Assist with deviations/non-conformances/OOS investigations in a timely manner. Routinely monitor, clean, prepare and operate sophisticated automated cell processing, cell expansion and filling equipment in cleanroom environments. Assist and Oversee training of personnel on aseptic processing, equipment operation, cGMPs, documentation, technical theory, or other tasks. Lead and oversee problem solving activities, tech transfer activities. Support process development of platform processes, contributing to the plans and designs of studies/experiments. Provide guidance and strategy for Manufacturing Execution systems (MES) and other digital systems used within manufacturing. Oversee non-routine activities on production floor. Ensures a safe work environment in accordance with AstraZeneca standards. Participate as Manufacturing representative on multiple cross-functional "working groups" collaborating as part of a process execution team at site. Timely and appropriate escalation to upper management, as well as cascade to all manufacturing staff members.

Minimum Qualifications:

Education:

Bachelor's degree in life sciences, engineering, or a related field

Experience:

3+ years of general cGMP manufacturing experience. 1+ years of experience of prior supervisory or management experience. Significant knowledge in biologics manufacturing process, cell culture and/or vector products. Demonstrated leadership, organization and time management skills. Proven logic and decision-making abilities, critical thinking and troubleshooting skills. Must be able and willing to work onsite shift days/hours of Wednesday-Saturday 0700-1730

Desirable Qualifications:

Experience:

5+ years of general cGMP manufacturing experience, including 1+ years of Cell Therapy experience. 3+ years of experience of prior supervisory or management experience.

Skills:

Previous manufacturing or process development experience with cell therapy or vector products. Dynamic individual with the ability to communicate and engage others. Independent and self-starting. Ability to work with minimal supervision. Demonstrate flexibility and willingness to change ways of working/identify opportunities to improve processes within cGMP clinical manufacturing environment. The annual base salary (or hourly rate of compensation) for this position ranges from $94,692•$142,366. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 20-May-2026 Closing Date 09-Jun-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We're curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We're driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you'll do work that has the potential to change your life and improve countless others. And, together with your team, you'll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.