Research Scientist 6 - Principal Investigator, Nathan S. Kline Institute for Psychiatric Research, P27142

Basics Schedule Location Job Specifics How to Apply NY HELP No Agency Mental Health, Office of Title Research Scientist 6 - Principal Investigator, Nathan S. Kline Institute for Psychiatric Research, P27142 Occupational Category Other Professional Careers Salary Grade 35 Bargaining Unit PS&T - Professional, Scientific, and Technical (PEF) Salary Range From $161476 to $193823 Annually Employment Type Full-Time Appointment Type Permanent Jurisdictional Class Non-competitive Class Travel Percentage 0% Workweek Mon-Fri Hours Per Week 40 Workday From 6 AM To 6 PM Flextime allowed? No Mandatory overtime? No Compressed workweek allowed? No Telecommuting allowed? No County Rockland Street Address Nathan S. Kline Institute for Psychiatric Research (NKI), Emotional Brain Institute 140 Old Orangeburg Road City Orangeburg State NY Zip Code 10962 Duties Description This Research Scientist will:

• Provide scientific direction for single-cell and spatial genomics initiatives, contributing to experimental design, assay implementation, and integrated multi-omic data analyses.
• Develop, optimize, and supervise laboratory workflows for single-cell, single-nucleus, and spatial transcriptomic and epigenomic assays, ensuring high-quality and reproducible data generation.
• Lead development of computational pipelines for large-scale genomics datasets, including scRNA-seq, snRNA-seq, scEpiegenome profiling, long-read sequencing, and spatial omics platforms.
• Integrate molecular, clinical, and behavioral data to advance translational psychiatry research and support NKI-NYU collaborative programmes.
• Guide and mentor multidisciplinary teams, including junior laboratory and computational staff, to ensure coordinated delivery of genomics research objectives.
• Generate rigorous analysis outputs, pilot datasets, and related materials that support manuscripts, presentations, and competitive grant submissions.

Minimum Qualifications Ph.D. and seven years of professional research experience in an appropriate field.

PREFERRED QUALIFICATIONS

• Active NIH funding as Principal Investigator, with at least one current R01 (or equivalent) grant that has a minimum of two years of remaining support at the time of application.
• Outstanding publication record in high-impact, peer-reviewed journals in the fields of systems neuroscience, neurodegeneration, or Alzheimer's disease research.
• Established expertise in in vivo electrophysiology in freely behaving rodents, including multi-electrode or multi-channel recording systems, local field potential analysis, and single-unit physiology.
• Proven experience with optogenetics and/or chemogenetics for circuit-level manipulation in the context of disease models.
• Excellent written and verbal communication skills; strong record of scientific communication including grant writing, manuscripts, and public presentations.
• Demonstrated ability to independently secure extramural research funding and manage a productive laboratory.
• Focused research expertise in Alzheimer's disease pathophysiology, with demonstrated experience using transgenic mouse models of amyloid-beta and/or tau pathology.
• Deep knowledge of the neurobiology of selectively vulnerable brain regions in AD, including the entorhinal cortex, hippocampus, and locus coeruleus, and their interconnected network dysfunction.
• Experience designing and executing behavioral neuroscience paradigms that measure spatial memory, associative learning, and executive function in rodent disease models.
• Track record of collaborative research with computational neuroscientists and biomedical engineers, particularly in the context of large-scale neural data analysis and circuit modeling.
• Prior experience mentoring and developing the careers of postdoctoral researchers and graduate students.
• Demonstrated engagement with the Alzheimer's disease research community, including participation in NIA or NINDS study sections, collaborative consortia, or advisory roles.
• History of multi-investigator or program project grant participation or leadership Additional Comments All OMH employees receive a generous benefits package including:
• NYS medical, dental, & vision insurance
• Access to tuition assistance programs
• Excellent opportunities for advancement & professional growth
• Paid time off - 13 paid vacation days in the first year, 5 paid personal days, 13 paid holidays, & paid sick leave
• NYS Retirement programs Background checks will be required.

This position is eligible for a Downstate Adjustment of $4,000.

Notes:

1. If you fail to maintain your license and/or registration once you are appointed, action will be taken to remove you from the position. 2. In order to be eligible for appointment and to maintain employment, you cannot be listed as an excluded individual or entity on any of the Federal and/or State Medicaid and Medicare exclusion lists (or excluded from any other Federal or Federally assisted program). If you are appointed and subsequently listed as an excluded individual or entity on any of these lists (or excluded from any other Federal or Federally assisted program), you may be terminated from your employment. 3. If appointed you may be required to become an enrolled Medicare provider; obtain and provide to your employer a National Provider Identifier (NPI) number issued by the National Plan and Provider Enumeration System (NPPES); and otherwise actively participate to the degree necessary to allow for your services to be billed through Medicare and Medicaid. If you are appointed and you lose the ability to bill through Medicare and Medicaid, you may be terminated from your employment. Some positions may require additional credentials or a background check to verify your identity. Name Andrea Smith, Human Resources Specialist 2 Telephone Fax 845-398-5418 Email Address employment@nki.rfmh.org Address Street The Nathan S. Kline Institute for Psychiatric Research 140 Old Orangeburg Road City Orangeburg State NY Zip Code 10962 Notes on Applying Indicate the Title and Location of the position you are applying for. Please include your e-mail address on your application/resume. Please complete the Office of Mental Health Employment Application and fax or email to above contact information.

https:

//omh.ny.gov/omhweb/employment/docs/employment-application.pdf The Mission of the New York State Office of Mental Health (OMH) is to promote the mental health of all New Yorkers, with a focus on providing hope and supporting recovery for adults with serious mental illness and children with serious emotional disturbances. Applicants with lived mental health experience are encouraged to apply. OMH is deeply committed to supporting underserved individuals, organizations and communities. To this end, OMH is focused on implementing activities and initiatives to reduce disparities in access, quality, and treatment outcomes for underserved populations. A critical component of these efforts is ensuring OMH is a diverse and inclusive workplace where all employees' unique attributes and skills are valued and utilized to support the mission of the Agency. OMH is an equal opportunity/affirmative action employer.