Research Associate Antibody Discovery and Development

Research Associate - Antibody Discovery and Development Employer TegMine Therapeutics, Inc. Location 94080, South San Francisco Start date Jun 17, 2026 View more categories View less categories Discipline Science/R D , Biotechnology , Oncology Required Education Bachelors Degree Position Type Full time Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details Unlock the Future of Cancer Therapeutics At TegMine Therapeutics, we're on a mission to restore futures lost too soon. Our antibody discovery and development platform is pioneering the next generation of cancer-specific therapeutic targets. We're dedicated to delivering best-in-class therapies for currently untreatable cancers. We are seeking a talented and motivated scientist to join our dynamic biologics discovery team. In this role, you will drive the generation, purification, and characterization of novel monoclonal antibodies (mAbs) and therapeutic protein formats. This is a hands-on position ideal for a researcher who thrives in a collaborative, fast-paced environment and enjoys bridging protein expression with downstream protein biochemistry to advance our therapeutic pipeline.

Key Responsibilities Protein Expression:

Execute transient and stable transfections in mammalian host systems ( CHO and HEK293 ) to optimize recombinant antibody yields.

Protein Purification:

Develop and run multi-step purification workflows using ÄKTA chromatography systems , utilizing Protein A affinity, ion-exchange (IEX), and size-exclusion chromatography (SEC).

Biochemical & Biophysical Characterization:

Evaluate antibody quality and purity using analytical methods such as SDS-PAGE, Western Blot, HPLC/UPLC , and UV-Vis spectrophotometry.

Process Optimization:

Proactively troubleshoot technical challenges and contribute to developing robust, scalable production protocols.

Data Analysis & Documentation:

Maintain meticulous experimental records in an Electronic Lab Notebook (ELN) . Analyze, interpret, and present data-driven insights clearly to cross-functional project teams. Qualifications & Experience Master's Degree in Molecular Biology, Biochemistry, Biotechnology, or a related field with 2+ years of industry experience, OR Bachelor's Degree in the same fields with 4+ years of relevant industry experience.

Technical Core Competencies Mammalian Cell Culture:

Proficient in sterile, aseptic techniques for maintaining and transfecting cell lines.

Downstream Processing:

Demonstrated expertise in protein purification using automated chromatography systems (AKTA)

Analytical Characterization:

Solid familiarity with standard protein analysis and HPLC platforms.

Soft Skills & Attributes Analytical Mindset:

Exceptional problem-solving skills with a keen attention to detail.

Operational Excellence:

Excellent organizational and time-management abilities to balance multiple priorities.

Collaboration & Communication:

A team-first attitude with the ability to work independently, paired with strong written and verbal communication skills. What we offer Equity in a promising start-up Comprehensive health coverage 401k & paid time off Opportunities for professional growth and development Compensation based on experience If you're passionate about innovation, thrive in a collaborative environment, and want to make a real impact, we'd love to hear from you! TegMine is an equal opportunity employer and does not discriminate based on any legally protected status. To apply, please email your resume and cover letter at futures@tegminetx.com Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert