Scientist, RNA Chemistry

Scientist, RNA Chemistry Employer Dyne Therapeutics Location Waltham, MA Start date May 16, 2026 View more categories View less categories Discipline Science/R D , Biotechnology , Chemistry Required Education Masters Degree/MBA Position Type Full time Hotbed Genetown Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job

Job Details Company Job Details Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities.

Learn more at https:

//www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook .

Role Summary:

As a member of the Platform team, the Scientist, RNA Chemistry will contribute to the development of Dyne's oligonucleotide chemistry platform and support the discovery of novel nucleic acid therapeutics. This individual is responsible for independent design and hands-on execution of oligonucleotides synthesis, purification, and analysis of oligonucleotides and their conjugates. The scientist will apply established methods, troubleshoot routine issues, and have technical expertise in modified RNA synthesis and independently produce high quality oligonucleotides using state-of-the-art lab equipment. This is a full-time position based in

Waltham, MA Primary Responsibilities Include:

Independently perform synthesis of modified RNA oligonucleotides (ASO, siRNAs) incorporating diverse sugar and backbone chemistries at scales suitable for both in vitro and in vivo studies. Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides of various lengths. Interpretation of analytical data (HPLC, LCMS) to enable improved purity and yields of synthesized oligonucleotides. Carry out purification (anion exchange, reverse phase), analysis (IP/RP, IEX, SEC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates. Register synthesized oligonucleotides in the database (sequence, lot, and QC) and precisely report experiments in the ELN. Contribute to the design of oligonucleotides against various targets and rationally perform the hit-to-lead optimization process. Generate intermediates to prepare antibody-oligonucleotide conjugates. Cross-functional collaboration to define deliverables and timelines. Multi-task across several projects and manage time effectively to achieve results. Perform lab maintenance activities in collaboration with peer scientists and lab operations. Collect, present, and discuss data at internal team meetings.

Education and Skills Requirements:

PhD in Chemistry or a related scientific discipline with 2 years of experience, or MSc with a minimum of 8 years of relevant industry experience in biotechnology or life sciences. Postdoctoral experience is a plus Hands-on experience operating oligonucleotide synthesis and purification platforms, including MerMade, K&A, and AKTA Oligopilot. Experience with oligonucleotide conjugation, including antibody conjugation, is a plus. Familiarity with biochemical and analytical assays used to assess stability, properties, and mechanism of action of modified RNA oligonucleotides. Independently executes experimental work within defined research projects, applying sound scientific methodology to address increasingly complex problems. Interprets and communicates experimental data to support program advancement and decision-making. Demonstrates strong cross-functional collaboration skills, working effectively with internal partners to advance shared scientific objectives. #LI-Onsite MA Pay Range $118,000 - $145,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Company Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit https://www.dyne-tx.com , and follow us on X and Facebook.

CONNECT Stock Symbol:

DYN Stock Exchange:

Nasdaq Company info Website https://www.dyne-tx.com/ Location 1560 Trapelo Road Waltham

MA 02451

United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert