Research Associate /Senior Research Associate Membrane Protein Biochemistry

Topo Therapeutics Topo Therapeutics is an early-stage startup biotech company headquartered in Watertown, MA. Topo's mission is to develop small molecule therapeutics for the treatment of neurological and rare diseases by leveraging novel insights into transmembrane protein structure and small molecule-protein interactions. Backed by top-tier life science investors, Topo brings together scientific founders who are world leaders in the fields of protein structure, neurobiology, and rare disease with a highly experienced team with industry-leading expertise in membrane protein pharmacology. Position Summary We are seeking a motivated and organized Research Associate with a strong background in biochemistry and tissue culture to join the Topo scientific team. This lab-based position will be primarily responsible for protein expression using a range of vectors and hosts, producing high quality protein reagents for biochemical and structural studies, and executing biochemical and biophysical assays for ligand discovery and MoA studies. The individual must be a very careful experimentalist. As time allows, the candidate may also provide support for other activities and experiments in the laboratory.

Qualifications:

Required Skills and Experience BA/BS in Biology, Biochemistry, or related discipline preferably with 2+ years in drug discovery in an industry position. 2+ years' experience in mammalian cell culture required. Experience with protein expression using a range of vectors and hosts required. Experience with membrane protein biochemistry including protein purification using

FPLC/HPLC

instruments required. Experience performing and analyzing biochemical, biophysical, or cell-based assays required. Strong interpersonal skills required. Excellent attention to detail, organizational skills, and computer literacy required. Desired Skills Experience with molecular biology techniques desired. Experience with small-molecule binding assays. E.g. DSF, SPR, ITC, fluorescence polarization, radioligand binding. Insect cell culture experience. If you are interested in exploring work opportunities at Topo, please submit your resume noting your specific position interest to: careers@topo-tx.com. Topo is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity, national origin, veteran status, or genetic information. Topo is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. Applicants must be authorized to work for ANY employer in the U.S. We are currently unable to sponsor or take over sponsorship of employment visas. Employment agencies are an important component of our talent acquisition strategy, and we value the partnerships we have built with our preferred vendors. We will not accept unsolicited resumes from employment agencies for any employment opportunity. All resumes submitted by search firms to any employee at Topo or directly to hiring managers in any form without a signed agreement between the parties will be deemed unsolicited in nature, and no fee will be paid in the event the candidate is hired as a result of the referral or through other means.