Post Doc Fellow

Employer:

City of Hope Job Number:

Date Posted:

2 months ago

Application Deadline:

Open Until Filled City of Hope Location:

Phoenix, AZ Job Number:

7324179 (Ref #: 3871631)

Posting Date:

2 months ago

Application Deadline:

Open Until Filled .eply-list > li{font-size:14px;padding:3px 0px;} .augusta-university h2{font-size:21px;} Job Description About the lab We are a newly established computational research group at the Translational Genomics Research Institute developing and applying pangenome methods to study genome variation and evolution. Our work builds on experience developing pangenome graph construction and analysis tools (PGGB, ODGI, IMPG) and contributions to the Telomere-to-Telomere Consortium and Human Pangenome Reference Consortium. We use long-read sequencing and de novo genome assembly to construct personalized pangenomes for cancer samples, detecting somatic structural variation that reference-based methods miss. We also aim to reduce the cost and complexity of germline genome assembly to make personalized pangenomics more routine in clinical and research settings. Additionally, we are developing pangenome-based approaches for genome-wide association studies. We are looking for a passionate and highly motivated postdoctoral fellow to join our team. Position summary The postdoctoral fellow will develop and apply computational methods for cancer pangenomics using long-read sequencing data. Through TGen's Collaborative Sequencing Center (CSC), we have access to in-house PacBio Revio and Oxford Nanopore PromethION platforms with skilled library preparation support, ensuring ample data. The candidate will also be encouraged to identify and pursue new research areas and ideas.

This position offers flexibility:

hybrid arrangements with on-site time at TGen in Phoenix are possible for the right candidate. Responsibilities Developing computational tools for analyzing and visualizing long-read sequencing data and genome assemblies in normal and tumor samples Constructing personalized pangenomes to characterize somatic structural variation Contributing to pangenome-based variant calling and association study pipelines Working with large-scale genomic, epigenomic, and transcriptomic data Contributing to genome assembly and comparative genomics analyses Collaborating with internal and external partners, including consortium colleagues (e.g., Telomere-to-Telomere Consortium, Human Pangenome Reference Consortium) Building and maintaining reproducible workflows (e.g., Snakemake, Nextflow) Presenting research internally and externally (e.g., conferences)

Required:

PhD in Bioinformatics, Computer Science, Computational Biology, or related field Experience analyzing DNA sequencing data Proficiency in Python and/or R Familiarity with Linux/Unix and HPC systems (SLURM) Experience with version control (Git/GitHub) Understanding of statistics for genomic analysis

Preferred:

Long-read sequencing analysis experience Proficiency in a compiled language (C, C++, Rust) Track record of software development (include a link to the software project you are most proud of) Familiarity with genome assembly, structural variant calling, or pangenome methods Experience with workflow managers Knowledge of cancer genomics databases (TCGA, ICGC) Experience with GWAS or variant-phenotype association analysis Familiarity with controlled-access genomic databases (e.g., dbGaP) Location The Guarracino Lab is located at the Translational Genomics Research Institute, a non-profit research institute in Phoenix, Arizona. Phoenix is the 5th largest city in the nation, ranked 5th as an Emerging Life Science Market, with over $3.25 billion in recent capital investment in biosciences. TGen sits at the center of the Phoenix Biomedical Campus, a 30-acre urban life sciences hub. Phoenix offers over 300 sunny days a year, multiple mountain ranges nearby, and access to some of the nation's most stunning national and state parks. The airport is a 10-minute drive from TGen with consistently high passenger satisfaction ratings. Benefits BC/BS of Arizona health coverage Dental, Vision, Life, Short and Long Term Disability 401k with 6% match Generous time off Commuter benefits Employee Assistance Program Application Please direct questions to [email protected] . Submit a cover letter describing your research interests and motivation for joining the group, along with a CV detailing your research experience, publications, conference presentations, and contact information for at least two references. Review of applications will begin immediately and continue until the position is filled. The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time. City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients' experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.