Cellular Biologist II - Stem Cell Array

Leveraging a new automated production platform, JAX's iPSC repository is projected to become the largest in the world by 2030 by expanding to several thousand lines and enabling next-generation applications in disease modeling and drug discovery. The new Cellular Models production facility will be housed at The Jackson Laboratory for Genomic Medicine in Farmington, CT. The Cellular Biologist works closely with departmental leadership and a multidisciplinary team of scientists and technical specialists. Responsibilities include, but are not limited to, project planning, method development, execution of laboratory procedures, adaptation of protocols, data collection and analysis, documentation, and contribution to reports and other written materials. The role requires strong mental focus, attention to detail, and proficient technical skills. This position may provide guidance and mentorship to junior staff, departmental assistants, and trainees, supporting their development within and beyond the assigned work area. Depending on project and operational needs, the role may require a flexible schedule, including occasional evening, weekend, or holiday shifts. In addition, the position involves regular collaboration with cross functional partners such as project managers, engineering teams, and software or technical support personnel to ensure smooth day to day laboratory operations in a production focused environment. The salary range is $52,712-$76,432. Salary will be determined based on qualifications and experience. The hired candidate will work at the JAX facility in Farmington, CT but may be required to travel to NYC for one week of training. Key Responsibilities & Essential Functions Primary responsibilities may include implementing and performing cell biology related tasks/procedures as well as dissociative, spatial, and in vitro single cell assays. Plan and monitor resources needed to conduct tasks such as the cell culture (manual or automated), spatial transcriptomics, and hyperplexed imaging technologies of the laboratory; maintain inventory control; coordinate space, field, equipment, and/or facilities; may monitor expenditures. Documentation of results; implement protocols from the literature; identify problems, troubleshoot, and analyze variations observed and reported in regular testing protocols; modify, refine, or adapt techniques and procedures; modify and/or adjust quality control measures . Lead exchange of information through demonstration and instruction. Other duties as assigned. Primary responsibilities are to perform and independently monitor automated and manual cell culture and related activities, and to pick, pack, and confirm the shipment of cells to domestic and international customers. Adapts protocols and develops new workflows with periodic support as required. Work collaboratively to perform all necessary protocols for workflows that include, but are not limited to, fibroblast expansion, reprogramming, iPSC expansion, and differentiations on the robotic platform(s), or manually as required. Store and withdrawal of specimens from liquid nitrogen and freezers, and prepare media and reagents required for daily work. Work closely with the laboratory operations team to ensure reagent/consumable inventory is accurately and efficiently stocked. Plan and monitor resources needed to operate the Global Stem Cell Array; maintain inventory control; coordinate space and field questions. You may be required to participate in the monitoring and tracking of resources/expenditures across projects. Collaborate with engineers and other staff when resolving more complex issues. Documentation and feedback are provided in a variety of ways including the creation Create and modify modification of SOPs, filing of file tickets to software and automation teams, and providing provide feedback at inter- and intra-team meetings.

Minimum Qualifications:

BS degree in biological science or related field 3+ years of prior relevant experience Experience in multiple techniques such as flow cytometry, FACS sorting, immunohistochemistry, immunofluorescence, in situ hybridization, and complex 3D cellular cultures May be required to demonstrate ability to develop and implement research protocols, shown through contributions to research publications (authorship) Demonstrated success in coordinating and/or conducting multiple, concurrent assignments or a multi-faceted project Ability to interact with all individuals in a productive, professional, and positive manner to enhance the outcome of the goals of the research program Experience with human/mammalian cell culture, with additional broad expertise in cell and molecular biology techniques, preferred. While not required, experience with liquid handling automation is preferred. Demonstrated ability to develop and improve biological workflows/processes, or have contributed to the development of automation/software tools. Demonstrated ability in coordinating and performing multiple, concurrent assignments across complex workflows. Ability to work in a fast-paced environment and interact with all individuals in a productive, professional, and positive manner to enhance the outcome of the goals of the research program. #CA-DS5

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Bar Harbor:

The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries.

Ellsworth:

The Charles E. Hewett Center in Ellsworth, Maine, is a state-of-the-art facility that serves researchers world wide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine's fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year-round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants.

Farmington:

JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine's research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state's capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports.

Sacramento:

The JAX® Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two-hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation's Farm to Fork movement, and offers excellent restaurants, gastro-pubs, wineries, theaters, and museums.

Outdoor activities are plentiful:

Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year.

Augusta:

JAX's Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.