Summer intern - Bioinformatics and Proteomics

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body's own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and "undruggable" targets, the company has three investigational clinical-stage programs currently enrolling: ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a

KRAS G12D PROTAC

for the treatment patients with solid tumors with

KRAS G12D

mutations. On August 8 th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant

• an investigational, orally bioavailable PROTAC estrogen receptor degrader
• for its use as a monotherapy in the treatment of adults with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2
• , ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy.

In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and mission

• to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We're really excited about the work we're doing inside and outside of Arvinas, and think you will be, too. But don't just take our word for it
• learn more about life at Arvinas and what employees have to say .

For more information, please visit www.arvinas.com . Position Summary Our Bioinformatics and Proteomics team is looking for a highly motivated individual to explore tools and approaches to optimize computational processes. There may be additional opportunities to aid in application development to allow the team to leverage both internal and external data to support our drug development programs. The intern will present results at team meetings and will summarize their work as a talk or poster at Arvinas at the conclusion of the internship. This position reports to the Senior Research Investigator, Bioinformatics and can be located remotely within the U.S. Principal Responsibilities Key responsibilities of this role include, but are not limited to: Help identify and process high dimensional data sets for analysis Utilize state of the art tools to help optimize code, workflows, or applications to analyze and visualize biological data Prepare and present results at an internal Arvinas function at the conclusion of the internship. Qualifications Proficiency in Python and/or R programming required; experience with Linux and AWS is a plus Knowledge and experience with data analysis & visualization, modeling, and machine learning methods and tools Knowledge and experience with AI tools for code and process optimization Experience working on neurobiology or cancer biology projects is desirable. Must be able to work effectively in both independent and team contexts. Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for current or future VISA sponsorship. The duties of this role are generally conducted in a combination of company office and home office environments. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

EDUCATION

Computational Biology, Bio informatics , Computer Science or related major ; candidates should be at least a rising junior/senior undergraduate or Master's program student Completed coursework related to neuroscience or cancer biology preferred Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.