Genetic Editing Scientist - Cell Therapy Discovery Program

The Mayo Clinic in Florida invites applications for an open-rank faculty position for an innovative and accomplished Genetic Editing Scientist to join and help lead the expanding Cell Therapy Discovery and Translational Science Program. This reflects Mayo Clinic Florida's commitment to accelerating next-generation of engineered cell therapies and to advancing curative treatments for cancer and non-malignant diseases. We seek an exceptional investigator with expertise in genome engineering and gene editing technologies (e.g., CRISPR/Cas systems, base editing, prime editing, epigenome editing, synthetic gene circuits, or related platforms) applied to human cells for therapeutic development. The successful candidate will play a central role in advancing a rapidly growing, multidisciplinary cell therapy program focused on discovery science, translational innovation, and clinical impact. A key component of this role will be close collaboration with established CAR-T and immune cell therapy scientists, leveraging advanced genetic editing strategies to enhance persistence, safety, resistance to exhaustion, efficacy, tumor microenvironment adaptation, and manufacturability. The candidate will be expected to work across oncology and non-oncology indications to develop novel gene-engineered approaches that expand the therapeutic reach of cellular therapies beyond cancer, including autoimmune, inflammatory, genetic, and degenerative disorders. Strategic Role and Leadership Expectations The Genetic Editing Scientist will: Provide scientific leadership in genome engineering strategies across the Florida campus cell therapy ecosystem. Partner closely with CAR-T investigators and translational immunotherapy teams to develop next-generation engineered immune cell platforms. Develop innovative gene editing solutions to improve efficacy, durability, safety switches, multiplex editing strategies, and precision targeting in both malignant and non-malignant disease settings. Build scalable and clinically translatable genetic engineering pipelines that accelerate progression from discovery to early-phase clinical trials. Contribute to the strategic growth and national visibility of Mayo Clinic Florida's Cell Therapy Program. Mentor trainees, junior faculty, and research staff within a collaborative and inclusive academic environment. Participate in institutional initiatives aligned with Mayo Clinic's vision to Cure, Connect, and Transform healthcare through transformative science. The successful candidate will be a key driver in integrating advanced genome engineering technologies into existing and emerging cell therapy platforms, enabling novel approaches to immune cell engineering, stem cell modification, in vivo gene editing strategies, and precision genome correction programs. Research Environment Mayo Clinic Florida offers a highly collaborative and integrated academic medical center environment with expanding strengths in cell therapy, cancer immunotherapy, regenerative medicine, and translational science.

Faculty benefit from:

Established CAR-T and immune cell therapy programs with active clinical translation State-of-the-art genome engineering and cell manufacturing infrastructure Access to institutional core facilities including genomics, single-cell sequencing, proteomics, bioinformatics, and advanced imaging Robust disease-focused centers supporting both oncology and non-oncology therapeutic innovation Dedicated institutional support for regulatory strategy, clinical trial development, and commercialization pathways Cross-campus collaboration opportunities with Mayo Clinic sites in Minnesota and Arizona The selected candidate will help shape a coordinated, forward-looking cell therapy strategy that integrates gene editing platforms with clinical translation infrastructure. Why Choose Mayo Clinic Florida? Mayo Clinic is a premier, integrated academic medical center consistently ranked among the top hospitals in the nation. The Florida campus is experiencing strategic growth in engineered cell therapy, cancer immunotherapy, regenerative medicine, and translational discovery science.

We offer:

Competitive startup and sustained institutional support Investment in team science and program-building initiatives Access to a $1B+ annual research enterprise Infrastructure for IND-enabling studies and early-phase clinical trials Exceptional benefits, including retirement and pension programs A culture that values innovation, inclusion, and transdisciplinary collaboration Qualified candidates must hold a doctoral degree (Ph.D., M.D., M.D./Ph.D., Sc.

D., or equivalent) in genetics, molecular biology, immunology, biomedical engineering, or a related discipline.

Candidates should demonstrate:

A strong record of high-impact, peer-reviewed publications in genome editing, immune engineering, or related fields. Sustained extramural funding appropriate to academic rank (NIH K award or equivalent for Assistant Professor; R01-level funding or equivalent for Associate Professor or higher). Experience collaborating across disciplines, particularly with immunotherapy or CAR-T research programs. Evidence of scientific leadership and the ability to build collaborative, multidisciplinary research programs. A demonstrated commitment to mentorship, education, and fostering an inclusive academic culture. Appointment level (Assistant, Associate, or Full Professor) will be commensurate with experience and years in rank, scholarly achievement, leadership experience, and funding record.