Research Fellow-PC-Gastroenterology-Huang lab

The Huang Laboratory at Mayo Clinic is a translational physician-scientist-led research program focused on developing next-generation, non-viral liver-directed gene therapy platforms for cancer and rare diseases. Our work centers on innovative hydrodynamic and endoscopic delivery approaches to enable efficient, liver-specific gene transfer and in situ production of therapeutic molecules. By integrating gene therapy, cancer immunology, and advanced endoscopy, our goal is to create scalable, safe, and re-dosable alternatives to viral vectors and to develop transformative treatments for gastrointestinal malignancies such as colorectal and hepatocellular cancer. The lab operates within a highly collaborative environment at Mayo Clinic, with strong connections to immunology, transplantation, bioengineering, and clinical trial programs, enabling rapid translation from bench to bedside. Research responsibilities We are seeking highly motivated postdoctoral fellows with a strong interest in gene therapy, immunotherapy, and cancer biology. Prior experience in one or more of the following areas is preferred: gene delivery systems (viral or non-viral), plasmid design, liver biology, cancer immunology, T-cell biology, antibody engineering, or in vivo animal models. Candidates should demonstrate strong scientific curiosity, independence, and commitment to translational research aimed at developing clinically impactful therapies. Technical Skills Experience with techniques such as molecular cloning, cell culture, flow cytometry or translational model systems is highly desirable. Preferred qualifications include proficiency in techniques listed below but not all required: Molecular biology skills: DNA/RNA isolation, qPCR, western blot, ELISA Immunology techniques: flow cytometry, immunohistochemistry Cell culture, transfection; protein extraction and quantification Molecular Cloning; Mini Midi Maxi prep; Establishing cell line with lentivirus Mice work: Mouse handling; Genotyping; Husbandry, Breeding; Tissue harvesting; Bleeding (we can provide training), Basical surgical skills (we can provide training), Tail vein injection (we can provide training) Ph.D. or M.D./Ph.D. in immunology, molecular/Cell Biology, bioengineering, or a related field Excellent analytical, written, and verbal communication skills are required Prior postdoctoral experience is helpful but not required