Research Associate II

Research Associate II Broad Institute paid time off, paid holidays, 401(k), retirement plan United States, Massachusetts, Cambridge May 15, 2026 Description & Requirements We are seeking an experimental research associate to join our team at the Broad Institute to build a comprehensive catalog of cellular programs across tissues. We are looking for highly motivated individuals to join this team to make fundamental discoveries in mapping and understanding cellular programs, and developing new tools to uncover mechanisms of disease. Our team develops and applies cutting-edge technologies combining CRISPR-based perturbations, single-cell measurements, and epigenomic profiling in human cells and tissues to understand genetic regulation in health and disease. The laboratory is a dynamic, highly collaborative, interdisciplinary environment within the Broad Institute. The successful candidate will work closely with lab members and collaborators across the Broad community on foundational efforts to understand the human genome and its role in health and disease.

KEY RESPONSIBILITIES

Collaborate with scientists and research associates to investigate gene regulation and disease genetics Develop and execute functional genomics experiments, including: CRISPR-based perturbation assays; Single-cell transcriptomic and epigenomic profiling; Cell-based assays in human tissues, primary cells and cell lines. Design and lead independent projects, including developing and optimizing experimental protocols and workflows Contribute to data generation, analysis, and interpretation, working closely with computational collaborators Make significant contributions to publications, presentations, and scientific discussions Help develop, document, and refine laboratory protocols and best practices Maintain strong organization of experimental workflows and lab resources Continuously learn and implement new technologies and methods, sharing knowledge with the team

QUALIFICATIONS

Bachelor's degree in Molecular Biology, Genetics, Biochemistry, or related field Additional 2+ years of relevant laboratory experience in academic or industry setting Hands-on experience in molecular biology, genomics, and/or cellular biology Mammalian cell culture (primary cells and/or cell lines) Standard molecular biology techniques Strong critical thinking, problem-solving, and experimental design skills Excellent organization, and time management skills Excellent interpersonal and collaborative skills, and the ability to work both independently and in a fast-paced, team-oriented environment Outstanding verbal and written communication skills Preferred Experience with: CRISPR genome editing Single-cell sequencing (RNA-seq, ATAC-seq, or similar) Stem cells (ES/iPS) or primary human cells Familiarity with high-throughput or pooled screening approaches Exposure to computational analysis or working closely with data scientists The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits. The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.