Postdoctoral Researcher

Summary A postdoctoral fellowship (with the possibility of continued support) is available in the Medical College of Wisconsin (MCW) Department of Physiology in the Chun Liu lab. The Liu lab develops and applies high-throughput functional genomics and human induced pluripotent stem cell (hiPSC) cardiovascular organoid models to identify mechanisms and therapeutic targets in genetic heart disease and cancer therapy-induced cardiovascular disease. We integrate CRISPR-based screening platforms (CRISPRi/a and knockout), Perturb-seq and multi-omics, and physiologically relevant 2D/3D human cardiac and vascular organoids, complemented by in vivo mouse models, to enable New Approach Methodologies that improve mechanistic insight and translational relevance. The postdoctoral fellow will lead projects that combine cardiovascular organoid with pooled CRISPR screens and single-cell readouts (e.g., Perturb-seq), and validate findings in complementary mouse studies. The postdoctoral fellow will create and follow an individualized development plan (IDP), conduct research studies, attend required courses/seminars, write grants, publish manuscripts, present oral presentations locally and nationally, and learn other skills necessary for a successful career in cardiovascular research. The postdoc is strongly encouraged to apply for internal or external fellowship funding such as the T32 postdoctoral fellowship offered by the Cardiovascular Center of MCW (if eligible) and the postdoc fellowship offered by the American Heart Association. Continued support for this position will be based on annual performance review. Interested applicants should apply online and attach their curriculum vitae, statement of research interests, and contact information of three references. Primary Responsibilities Work under the mentorship of the principal investigator and mentoring team to develop research projects consistent with the aims of the research program. This would require a thorough investigation of background information pertinent to the research program and an ability to understand the theoretical basis of the work being performed. Under the guidance of the faculty mentor and mentoring team, create and follow an individualized development plan (IDP) with foundational elements including, but not limited to progressive responsibility, coordination across multiple levels of translation, interactions with other cardiovascular and non-cardiovascular scientists, peer-to-peer learning opportunities, and specific coursework, seminars, and conferences for training in core competencies such as the ethical conduct of research, writing and critique of grants and manuscripts, study design and management, mentoring, teamwork, networking, and oral presentations. Design and execute laboratory experiments specific to the aims of research. Troubleshoot assays and customize experimental tools to answer research questions. Coordinate external and internal resources necessary for completion of research plan. Generate clear, complete, and timely records of experimental work. Participate in meetings with principal investigator and research staff to evaluate and interpret the validity of data, develop methodologies, and assess lab procedures. Communicate results of research at meetings and actively participate in publication of results. Attend pertinent research seminars and investigate new research articles at the request of principal investigator and on own volition. Ability to work well in a collaborative research team is required. Periodically mentor undergraduate and graduate student in a laboratory setting. Knowledge

• Skills
• Abilities Ability to maintain mouse colonies, performing animal surgeries, and in vivo cardiovascular phenotyping is preferred.

Mammalian cell culture and common molecular techniques is required. Generating and/or analyzing multi-omics datasets and CRISPR editing is preferred. Proficiency in written and spoken English, with a special emphasis on technical writing, is required. Documentation, records management and data utilization. Complex problem solving, critical thinking, and resource management

Qualifications Minimum Required Education:

PhD in life science or biomedical research fields, or

MD Minimum Required Experience:

0 years of previous postdoc experience

Preferred Experience:

Cardiovascular Biology, Stem Cell Biology, or Functional Genomics/CRISPR Required Certification/Licensure(s): Collaborative IRB Training Initiative (CITI) or similar Human Research Protections Certification and/or Required Animal Laboratory Use or other Biosafety Training to be completed in first month of employment Physical Requirements Work requires occasionally lifting moderate weight materials, standing, or walking continuously. Work Environment Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment. Sensory Acuity Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects. Why MCW? Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options 403B Retirement Package Competitive Vacation and Paid Holidays offered Tuition Reimbursement Paid Parental Leave Employee & Family Assistance Program (EFAP) Pet Insurance On campus Fitness Facility, offering onsite classes Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc. For a brief overview of our benefits see: Benefits Overview For a full list of positions see: MCW Careers At MCW all of our endeavors, from our internal operations to our interactions with our partners, are driven by our shared organizational values: Caring

• Collaborative
• Curiosity
• Inclusive
• Integrity
• Respect.

We are committed to fostering an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we recognize that a healthy and thriving community starts from within. Our values define who we are, what we stand for and how we conduct ourselves at MCW. If you believe in embracing individuality and working together according to these principles to improve health for all, then MCW is the place for you. For more information, please visit our institutional website. MCW as an Equal Opportunity Employer and Commitment to

Non-Discrimination:

The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic. About Us Together, we can build a healthier world. A student, an educator, a scientist and a community leader — alone, they can do many things. Together, the question isn't what they can do, but what can't they. The Medical College of Wisconsin (MCW) brings together the most inquisitive, passionate minds in science, medicine, education and community engagement to tackle today's toughest challenges in health and society. Academic medicine is at the center of where scientists, physicians and students work hand-in-hand with the community to ask the most important questions and fuel the cycle of innovation that shapes the future of medicine. Medical College of Wisconsin The tireless pursuit of knowledge and the power of academic medicine is at the core of everything we do at MCW. Bringing together the world's top scientists and clinicians, inspired students and invested communities, we are driven to solve the most complex challenges in health and society. With around 1,600 full-time and part-time faculty and approximately 3,500 full-time employees, MCW is home to a diverse group of thought leaders working in collaboration to pioneer pathways to a healthier world and drive a continuous cycle of life-changing discovery.