Director/Sr. Director/Exec. Director Computational Biophysics, Advanced Molecular Design (AMD)

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

• Location
• s•:•Louisville, Colorado•and Indianapolis, Indiana•Reports to:•Associate VP•,•Computational Chemistry,•AMD•

Overview:

• At Lilly, we serve an extraordinary purpose.

We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. The Lilly Small Molecule Discovery group is an organization purpose-built to create molecules that make life better for people. We focus on using cutting edge science to unlock new approaches that can treat people suffering from diseases with poor treatment options. We continually challenge ourselves to deliver molecules that can provide breakthrough efficacy with the highest possible safety margins. We are dedicated to optimizing our mindset, technology, and processes for faster, more nimble execution. Our success is built on a culture that empowers innovative problem solving through open collaboration and individual accountability.

• Position Summary:

• Lilly's Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid progress toward new clinical candidates for patients in need.

The AMD team is seeking an exceptional computational biophysicist to tackle the problems our discovery teams have yet to solve. _This is not a traditional computational chemistry role_ — it is a scientific leadership position for someone who sits at the intersection of deep physical theory, computational methods, and AI-enabled data analysis, and uses that combination to transform intractable problems into tractable ones. The ideal candidate engages with discovery teams when new perspectives, analyses, or solutions are needed, revealing understanding buried in datasets and structures, and provides teams with fundamentally deeper understanding leading to new paths forward. The position requires thinking at the level of first principles, building whatever tools are necessary, and measures success not by workflows delivered but by scientific understanding created.

• Responsibilities:

• + Develop and deployadvancedphysics-based algorithmstocharacterizebiophysical processesandtheir applicationacross a range of therapeutic areas + Play a key role in prioritizingcomputational methods and workflows toefficiently and effectivelyenable drug discoveryeffortsleadingto highly focused work and rapid progress + Ensure thetimelydelivery ofdata and resultsto project teamstoenable rapiditerative design cycles + Maintain critical timelines and setteam expectationsfor theefficientdeliveryofcomputational technologieswith strong impactontherapeuticprograms + Work closely with other AMD and therapeutic area leaders tomoveour portfolio of molecules from leads to quality drug candidatesthat havea strong potential to become breakthrough drug + Contribute to theongoingevaluation of external technologies •Basic Requirements•: + Ph.

D.in physics, chemistry, mathematics, computerscienceor related discipline + 10or moreyears of research experience

• Additional Preferences
• :•+ A deep scientific background intheoretical andcomputationalbiophysics + Proventrack recordofleadership andsuccessapplyingcomputational biophysicstowardadeeperunderstanding ofstructure-functionrelationshipsin human health + Proactive and effectivecollaborationwithcomputational chemists,medicinal chemists, structural biologists, and otherdisciplinesto achieve project goals and timelines + A strong desiretoestablisha deeper understanding of all aspects of drug discovery, includingconformationalensemblesof biological systems,small molecule-protein interactions,physicochemical properties, and

ADME + A

proactive and highly engaged approach to solving challenging problems indrugdiscovery + A desire tostaycontinually up to date with the latest industry developments and novel techniques employed in discovery,includingstatistical mechanics,free-energy and enhanced sampling methods,AI,and machine learning models + Excellent communicationof goals and priorities todiscoveryteams + Agility andadaptabilitytochangeresearchprioritiesas necessaryfor success + A commitment to mentoringearlier careerscientists + Strong core desiretohelp patients in need

• Physical Demands/Travel:

• The physical demands of this job are consistent with an office environment

.

• _The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job._ _Travel may be_ _required_ _._

• Work Environment:

• This is an onsite position located in one of the established Lilly Small Molecule Discovery sites in Louisville, Colorado or Indianapolis, Indiana. _The_ _work_ _environment_ _characteristics_ _described_ _here_ _are_ _representative of those an employee encounters while performing the essential functions of this job._ _
• To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily.

The requirements listed above are representative of the knowledge, skill, and/or ability_ _required_ _. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions_ Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees.

Our current groups include:

Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $193,500 - $338,800 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. \#WeAreLilly