Scientist Off-Target Genomics (Gene Therapy)

Company DescriptionAt Eurofins Professional Scientific Services (PSS), the work we do matters—and so do our employees. We are committed to supporting your professional growth by providing opportunities to enter and advance within the biopharmaceutical industry. Our teams are collaborative and supportive, offering the tools and environment needed to succeed while maintaining work-life balance and a competitive benefits package.

Eurofins Scientific is a global leader in life sciences, delivering a broad range of analytical testing services across industries including pharmaceuticals, food, environmental, and clinical research. Our work helps ensure product safety, quality, and compliance, contributing to a healthier and more sustainable world.

Job DescriptionWe are seeking a Scientist - Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects, genomic integrity, and emerging genome editing modalities.

Key Responsibilities:

Lead genomic safety assessment packages, including off-target discovery, verification, validation, and genomic integrity characterizationApply and evaluate off-target discovery approaches using:

In silico tools (e.g., CALITAS, CRISPRme, Cas-OFFinder)Biochemical methods (e.g., SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq)Cell-based assays (e.g., GUIDE-seq, INDUCE-seq)Drive off-target confirmation using sequencing-based approaches such as AmpSeq, rhAmpSeq, and hybrid captureAssess genomic integrity using orthogonal platforms including karyotyping, optical genome mapping, and whole genome sequencing (WGS)Evaluate genotoxicity risks associated with next-generation genome editing technologies, including base and prime editingSupport and/or lead development of novel assays for emerging genome editing modalities (Gen 5+)Integrate biodistribution data to inform tissue selection for off-target verification studiesCollaborate cross-functionally and present findings clearly to scientific and project teams

QualificationsMinimum Qualifications:

B.S. with 5+ years, M.S. with 3-7 years, or Ph.D. with 2-4 years of industry experience in genomics, molecular biology, biochemistry, or a related fieldHands-on experience in off-target assessment and/or genomic safety evaluation for gene editing therapeuticsStrong working knowledge of CRISPR-based genome editing technologiesExperience with next-generation sequencing workflows and data interpretationFamiliarity with base editing, prime editing, and associated genotoxicity considerationsDemonstrated scientific problem-solving skills; assay development experience is a plusStrong communication skills with the ability to present complex data to diverse audiencesSelf-motivated, adaptable, and able to work both independently and collaboratively

Preferred Qualifications:

Experience with optical genome mapping (e.g., Bionano platform)Understanding of regulatory expectations for genomic safety (IND/BLA submissions)Exposure to human diversity-informed off-target methods (e.g., ONE-seq)Authorization to work in the U.S. without sponsorshipAdditional InformationThe position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to applyWhat to Expect in the

Hiring Process:

10-15 Minute Phone Interview with Regional Recruiter45-60 Minute Virtual Interview with Manager and/or Group Leader45-60 Minute In-Person Meeting for a Casual Discussion of the

RoleWhat We Offer:

Excellent full-time benefits, including comprehensive medical coverage, dental, and vision optionsLife and disability insurance401(k) with company matchPaid vacation and holidaysYearly goal-based bonus & eligibility for merit-based increasesAnnual Compensation is $104,000 - $112,320, depending on education and experience Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.