Postdoctoral Fellow-MSH-30040-231

Description Title:

Postdoctoral Fellow, Organic Synthesis and Medicinal Chemistry Salary:

$75,000

Department:

Pharmacological Sciences Physical work location: Icahn Medical Institute, 1425 Madison Ave., NY, NY 10029

Name PI or Supervisor:

Professor Robert J. DeVita Ph.D. Web link to

Lab:

https://labs.icahn.mssm.edu/devita-lab/ Web link to

Department:

https://icahn.mssm.edu/about/departments/pharmacological-sciences

Administrative Contact:

Yoori Kim, 212-6598651, yoori.kim@mssm.edu

Responsibilities Details of Research Project:

The DeVita Lab of the Drug Discovery Institute and Dept of Pharmacological Sciences pursues novel drug targets in collaboration with clinicians and PI labs at Mt Sinai as a collaborative approach for translational science to develop new therapeutics for unmet medical needs. Active projects include projects directed to treat diabetes, IBD/Crohn's disease, cancer and rare genetic diseases. Educational and other Requirements for the position: PhD in organic synthesis required with knowledge of heterocyclic chemistry, organometallic chemistry and structure-based drug design using the Schrodinger suite desired.

Technical Duties:

(include any protocols): The role will require synthesis of novel medicinal compounds for testing in in vitro and in vivo assays that support the basic biology, translational science and drug discovery research efforts.

Qualifications Experience Required:

Preparation, purification and characterization of compounds in chemistry laboratory; documentation of all experiments in electronic lab notebooks (ELN) including written, publication quality, experimental procedures. Operation and maintenance of laboratory instruments - HPLC and LC-MS, for example. Safe laboratory habits and experimental practices. Strong collaboration skills with chemistry team members and biology collaborator labs. Essential Skills Strong background in organic chemistry in the area of organic synthesis, heterocyclic and organometallic chemistry; compound purification, characterization using NMR spectroscopy and analysis of reaction products using TLC and LC-MS techniques; methodology development; design of novel analogs; design and testing of synthetic routes to desired, novel compounds. Competence in Schrodinger suite of software for structure-based drug design and ligand docking is desired. 90% in lab medicinal chemistry; 10% structure-based drug design. Preferred Knowledge, Skills and Capabilities Earned doctorate in organic chemistry with specific experience in total synthesis, heterocyclic and organometallic chemistry; demonstrated experience in the synthesis, purification, and analysis of complex organic molecules; experience with new method development, rapid analog and library synthesis techniques; multi-step synthetic processes and larger, multi-gram reaction scale-up. Microwave assisted synthesis. Excellent reaction trouble shooting skills. Experience with the safe handling of reactive and air-sensitive materials. Characterization of new molecules by NMR and LC-MS. Competence with Schrodinger suite of software for structure-based drug design and ligand docking is desired with training available for those with an interest to learn this capability. Excellent English written and oral communication skills. Ability to prepare and document experimental procedures for manuscript submission, patent applications with journal quality submission. Goals/Outcomes of the

Research Project:

Development of small molecules as potential therapeutics for unmet medical needs. Patent applications and publications resulting from the small molecule drug discovery medicinal chemistry efforts. , 858 - Pharmacological Sciences - ISM, Icahn School of Medicine Employer Description Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai's unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the

Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

Qualifications:

Experience Required:

Preparation, purification and characterization of compounds in chemistry laboratory; documentation of all experiments in electronic lab notebooks (ELN) including written, publication quality, experimental procedures. Operation and maintenance of laboratory instruments - HPLC and LC-MS, for example. Safe laboratory habits and experimental practices. Strong collaboration skills with chemistry team members and biology collaborator labs. Essential Skills Strong background in organic chemistry in the area of organic synthesis, heterocyclic and organometallic chemistry; compound purification, characterization using NMR spectroscopy and analysis of reaction products using TLC and LC-MS techniques; methodology development; design of novel analogs; design and testing of synthetic routes to desired, novel compounds. Competence in Schrodinger suite of software for structure-based drug design and ligand docking is desired. 90% in lab medicinal chemistry; 10% structure-based drug design. Preferred Knowledge, Skills and Capabilities Earned doctorate in organic chemistry with specific experience in total synthesis, heterocyclic and organometallic chemistry; demonstrated experience in the synthesis, purification, and analysis of complex organic molecules; experience with new method development, rapid analog and library synthesis techniques; multi-step synthetic processes and larger, multi-gram reaction scale-up. Microwave assisted synthesis. Excellent reaction trouble shooting skills. Experience with the safe handling of reactive and air-sensitive materials. Characterization of new molecules by NMR and LC-MS. Competence with Schrodinger suite of software for structure-based drug design and ligand docking is desired with training available for those with an interest to learn this capability. Excellent English written and oral communication skills. Ability to prepare and document experimental procedures for manuscript submission, patent applications with journal quality submission. Goals/Outcomes of the

Research Project:

Development of small molecules as potential therapeutics for unmet medical needs. Patent applications and publications resulting from the small molecule drug discovery medicinal chemistry efforts. , 858 - Pharmacological Sciences - ISM, Icahn School of Medicine