Scientist I, In Vivo Pharmacology

Scientist I, In Vivo Pharmacology Employer Nurix Therapeutics Location Brisbane, CA Start date Apr 10, 2026 categoriesView less categories Job Details Company Job Details Scientist I, In Vivo Pharmacology Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Nurix is seeking a motivated and detail‑oriented Scientist I/II to join our Preclinical Pharmacology group with a primary focus on in vivo pharmacology and pharmacokinetics (PKPD) and inflammatory and autoimmune diseases. The position We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in inflammation. The ideal candidate will have expertise in small molecule PK/PD studies, inflammatory disease models, and immune cell profiling by flow cytometry. This hands‑on Scientist I/II role focuses on rodent models of inflammatory skin disease to characterize PK, PD, efficacy, and safety of therapeutic candidates. The candidate will establish new disease models in house. The scientist will design and execute skin inflammation studies, dose, collect and process blood, skin, and lymphoid tissues, and support ex vivo/in vitro immunology and molecular assays. The position is bench and vivarium based, requiring strong animal‑handling skills, experience with AD‑ and psoriasis‑like models, rigorous electronic documentation, and close collaboration with Discovery Research, DMPK, and other cross‑functional teams. At the Scientist II level, the individual will also be responsible for selected models or workflows, troubleshoot, implement technical improvements, and mentor junior staff. This is an excellent opportunity for a hands‑on in vivo scientist who enjoys bench work and wants to contribute directly to the generation of high‑quality data that drive target validation, lead optimization, and clinical candidate selection. Qualifications Job level will be commensurate with experience. Ph.D. in pharmacology, cancer biology, immunology, or related field with relevant post-doctoral or industry experience; or

B.S./M.S.

in Pharmacology, Pharmaceutical Sciences, Biology, or related discipline

Experience Sci I:

typically ≥1 year (Ph.D.), ≥4 years (M.S.), or ≥8 years (B.S.)

Experience Sci II:

typically ≥4 year (Ph.D.), ≥8 years (M.S.), or ≥12 years (B.S.) Knowledge of PK/PD concepts and basic pharmacokinetic analysis Excellent hands-on skills, including IV, PO, intradermal, and topical dosing, and blood/tissue collection Experience with inflammation, immunology, or dermatology disease models (e.g., MC903/AD, imiquimod psoriasis, contact hypersensitivity, PCA, pruritus/itch, CIA, EAE) and associated clinical scoring. Experience with PD biomarker assessment (e.g., ELISA/multiplex cytokines, Western blot, flow cytometry, qPCR); multiparameter flow cytometry for immune cell phenotyping, ex vivo stimulation assays, cytokine release, or proliferation assays is preferred. Experience working with electronic lab notebooks and data analysis/graphing software (e.g., Excel, Prism, FlowJo or similar). Excellent communication and presentation skills, with strong interpersonal skills and the ability to work productively in a highly dynamic, cross-functional environment. Fit with Nurix Culture and Values Strong team orientation; highly collaborative; solutions and results-oriented focus Strong scientific curiosity and initiative; hands-on and resourceful Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Location:

Brisbane, CA Salary Range:

Scientist I:

$127,216.00 - $144,156.00 Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (nurixtx/privacy-policy/). Company Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California. Company info