Principal Research Scientist, QTAS & ADME Sciences

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description AbbVie isseekinga highly motivated and experienced scientist to join ourQuantitative, Translation & ADME Sciences(QTAS)team in North Chicago.

The ideal candidate will haveastrong background andexpertisein drug metabolizing enzymefunction, drug-drug interaction concepts, quantitative bioanalysis, ability to drivecutting-edgescienceandlead a team of junior scientists. Applicants having experience in anadjacent area, such asdrugpermeability andtransport,receptor pharmacologyandpharmacokineticmodelingisdesirable. In this exciting role, you will be expected toparticipateinimplementinginnovative and quantitative approachesto advancetranslationalADMEusingconventional as well asmorecomplexin vitro models.

Working in a laboratory and non-laboratory setting, the position will involve the conductand scientific leadershipof in vitro assays as well asapplying translational modeling conceptstohelpdrive the globalin vitro ADMEstrategy at AbbVie.

The candidatewill beexpected toimplement and/or evaluatenew technologiesand approaches to support the mechanistic and translational understanding ofearly and late-stagesmall molecules tofacilitaterapid advancement ofdrug candidates in ourpipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience andexpertisewarrants.

Core responsibilities include:

Evaluating novel in vitro tools and methods,andapply established methodsand conceptsto enable and improve prediction ofhuman PKand drug-drug interaction potential Lead,mentorand coachjunior staffinestablished and novelpractices in vitro drug metabolism Liaise withQTAS, discovery biology/pharmacology/chemistryscientists to generate data and knowledge supporting the build-up of translational, mechanistic models Communicate internally and externally on topics related toin vitro drug metabolism Keep up to date with emerging literature and science in modelingand in vitroapproaches Externalize research in the form offull lengthpublications and oral presentations.

Qualifications BasicQualifications:

BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in area or scientific area of discipline Experiencewithin vitro ADMEexperiments andDMPKprojects, through academic or industry work. Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment Strong and relevant publication record as well asatrack recordof strategic scientific leadership in the in vitro ADMEfield Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor Passion forgenerating ideas,learning,solving technicalproblemsand applyingnew technologiesto further scientific goals.

Key Leadership Competencies:

Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance Ability to inspire and lead othersin areas of yourexpertise Learns fast, grasps the "essence"and can change course quicklywhereindicated Raises the bar and is never satisfied with the status quo Creates a learning environment, open to suggestions and experimentation for improvement Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof thisposting based on the job grade for this position.

Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible toparticipatein our long-term incentiveprograms.

Note:

No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.

The amount and availability of any bonus,commission,incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless anduntil paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html