Job Description
About Us Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation chemo proteomics RAPID platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet need. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including immune-mediated and rare diseases. Jnana's lead program is a potential first-in-class oral approach, targeting an allosteric site on the phenylalanine transporter SLC6A19, for the treatment of phenylketonuria (PKU), a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, a highly experienced management team and the backing of its parent company, Otsuka Pharmaceuticals. For more information, please visit www.jnanatx.com and follow us on Twitter and on LinkedIn. About the Opportunity Jnana Therapeutics is seeking an enthusiastic and highly motivated In Vivo Biologist to work in our multidisciplinary Translational Pharmacology group. At Jnana, we use our novel hit generation platform with a range of cell-based assays, our research aims to unlock difficult to drug targets. This opportunity is for an individual who strives to innovate and is never satisfied with routine. This person will be collaborating with Biology and Chemistry groups to design and implement mouse models of PK/PD and efficacy for autoimmune diseases. Prior experience in drug discovery, particularly in the area of autoimmune disease models, cytokine analysis and multi-color flow cytometry is desired. Must have strong technical experience handling, dosing, and sampling from mice. Strong commitment and work ethic are essential. Responsibilities Assist in design and implement acute PK/PD models to screen novel compounds for autoimmune targets. Validate and utilize mouse models of autoimmune disease including models of colitis, SLE, atopic dermatitis, psoriasis and asthma to interrogate novel compounds. Ex-vivo assessment of study samples using MSD, ELISA, and multi-color flow cytometric analysis. Must be able to work with project teams as an In Vivo Lead to understand project goals and collaborate on how to address them. Occasional weekend monitoring/dosing of studies. Preferred Qualifications & Past Experience MS in Pharmacology, Biology, or other relevant area with 5+ years of industry experience or PhD in Pharmacology, Biology or other relevant area with 0-2 years industry experience. Must be competent in IV, PO, SC and IP dosing of mice, in-life, and terminal blood collections. Experience running PK/PD models and mouse models of autoimmune disease. Many different techniques will be used, and training may be provided, but a desire to quickly gain independence is important. Demonstrate strong communication skills and attention to detail. Must be a scientifically motivated self-starter, able to work effectively in a fast-paced team environment. Minimum $98,400.00 - Maximum $141,450.00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate's job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws.
Application Deadline:
This will be posted for a minimum of 5 business days. Company benefits:
Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits. Come discover more about Jnana and our benefit offerings; https://www.jnanatx.com/join-us/ Disclaimer:
This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Jnana Therapeutics reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Jnana Therapeutics is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic. If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation, if you are unable or limited in your ability to apply to this job opening as a result of your disability. You can request reasonable accommodations by contacting Accommodation Request. Statement Regarding Job Recruiting Fraud Scams At Jnana Therapeutics we take security and protection of your personal information very seriously. Please be aware individuals may approach you and falsely present themselves as our employees or representatives. They may use this false pretense to try to gain access to your personal information or acquire money from you by offering fictitious employment opportunities purportedly on our behalf. Please understand, Jnana Therapeutics will never ask for financial information of any kind or for payment of money during the job application process. We do not require any financial, credit card or bank account information and/or any payment of any kind to be considered for employment. We will also not offer you money to buy equipment, software, or for any other purpose during the job application process. If you are being asked to pay or offered money for equipment fees or some other application processing fee, even if claimed you will be reimbursed, this is not Jnana Therapeutics. These claims are fraudulent, and you are strongly advised to exercise caution when you receive such an offer of employment. Jnana Therapeutics will also never ask you to download a third-party application in order to communicate about a legitimate job opportunity. Scammers may also send offers or claims from a fake email address or from Yahoo, Gmail, Hotmail, etc, and not from an official Jnana Therapeutics email address. Please take extra caution while examining such an email address, as the scammers may misspell an official Jnana Therapeutics email address and use a slightly modified version duplicating letters. To ensure that you are communicating about a legitimate job opportunity at Jnana Therapeutics, please only deal directly with Jnana Therapeutics through its official Jnana Therapeutics Career website https://www.jnanatx.com/join-us/. Jnana Therapeutics will not be held liable or responsible for any claims, losses, damages or expenses resulting from job recruiting scams. If you suspect a position is fraudulent, please contact Jnana Therapeutics call center at: 800-363-5670. If you believe you are the victim of fraud resulting from a job recruiting scam, please contact the FBI through the Internet Crime Complaint Center at: https://www.ic3.gov, or your local authorities. Jnana Therapeutics, Inc. does not accept unsolicited assistance from search firms for employment opportunities. All CVs/resumes submitted by search firms to any Jnana employee directly or through Jnana's application portal without a valid written search agreement in place for the position will be considered Jnana's sole property. No fee will be paid if a candidate is hired by Jnana as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune-mediated diseases. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, and a highly experienced management team. For more information, please visit www.jnanatx.com and follow us on Twitter/X and LinkedIn. At Jnana, you'll join a diverse, passionate team dedicated to advancing therapies for challenging diseases. Our collaborative, purpose-driven culture fosters innovation, urgency, and belonging—making Jnana a great place to work!
