Head of In Vivo Pharmacology

Head of In Vivo Pharmacology at Barrington James Drug Discovery & Preclinical Head of In Vivo Pharmacology at Barrington James Drug Discovery & Preclinical in Newtonville, Massachusetts Posted in 8 days ago.

Type:

full-time

Job Description:

Head of In Vivo Pharmacology Our client is seeking an innovative Head of In Vivo Pharmacology to lead preclinical pharmacology strategy and execution across a growing drug discovery portfolio. Based in the heart of Cambridge's world-renowned biotech ecosystem, this leadership role will be instrumental in advancing novel therapeutic programs from target validation through candidate selection and IND-enabling studies. The successful candidate will combine scientific excellence with strong leadership capabilities, driving the development and implementation of robust in vivo strategies while building and mentoring a high-performing team of scientists. Key Responsibilities Provide scientific and strategic leadership for all in vivo pharmacology activities across preclinical-stage programs Design, oversee, and interpret complex in vivo studies to support target validation, mechanism-of-action investigations and translational research Lead and develop a multidisciplinary team of in vivo scientists, research associates, and external collaborators Partner closely with Discovery Biology, Translational Sciences, DMPK, Toxicology, Biomarkers, and Clinical Development teams to ensure seamless program progression Drive the identification, validation, and implementation of relevant disease models and translational endpoints. Serve as a key contributor to project teams, governance committees, and portfolio review meetings. Manage external CRO relationships and oversee outsourced in vivo studies when appropriate. Support regulatory submissions, due diligence activities, and interactions with investors, partners, and scientific advisors. Champion animal welfare, ethical research practices, and the implementation of the 3Rs Required PhD in Pharmacology, Biology, Neuroscience, Immunology, Oncology, or a related life sciences discipline 10+ years of industry experience within biotechnology, pharmaceutical, or CRO environments. Deep expertise in experimental design, pharmacology, disease models, and data interpretation Proven leadership experience managing and developing scientific teams Strong understanding of translational research and the integration of preclinical data into development strategies Excellent communication, presentation, and stakeholder management skills. Experience within oncology, immunology, inflammation, neuroscience, metabolic disease, or rare diseases would be advantageous What We Offer Opportunity to lead a critical scientific function within a dynamic and growing biotechnology company Competitive compensation package including bonus and equity participation Comprehensive healthcare, retirement, and wellness benefits Collaborative, science-driven culture with access to leading academic and industry networks Significant opportunity for career growth and strategic influence within the organisation