Associate Scientist - CPDR

Join the HJF Team! HJF is seeking an Associate Scientist that will be responsible for developing and supervising research projects and investigating the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems. The incumbent will work in collaborative research environment alongside scientific and clinical investigators to initiate and carry out research projects. This position will be in support of the Center for Prostate Disease Research (CPDR) within the Murtha Cancer Center Research Program (MCCRP) located at the Rockledge Offices in Bethesda, Maryland. HJF provides scientific, technical, and programmatic support services to the MCCRP and CPDR. The Cancer Epigenetics, Cell Plasticity and Therapeutics Laboratory led by Dr. Leigh Ellis at the Center for Prostate Disease Research (CPDR) is seeking a talented and motivated Associate Scientist with working knowledge of molecular biology, 3D organoid and in vivo modeling and basic knowledge of single cell omics and spatial profiling. This position provides excellent opportunities for continued scientific development and contributions at the interface between research and administration in a dynamic laboratory environment and larger interdisciplinary setting. The Ellis laboratory interests include the characterization of comprehensive molecular signatures, survival pathways and associated rational therapeutic targets in lethal prostate cancers, with a specific focus on epigenetics and phenotypic plasticity in both cancer cells and the tumor microenvironment, and their role in disease progression and therapeutic resistance. To achieve this, we generate and utilize novel genetically engineered mouse models, human and mouse 3D organoid cultures, therapeutics, functional genomics, and molecular and genomic approaches (including next generation sequencing platforms, and CRISPR/Cas9 technology). CPDR is an interdisciplinary translational prostate cancer research program of the Uniformed Services University of the Health Sciences (USUHS) Department of Surgery and the John P. Murtha Cancer Center Research Program at the Walter Reed National Military Medical Center. Established in 1992 (Public Law 102-172), CPDR's mission is fulfilled primarily through its three principal programs: (1) the Clinical Translational Research Center; (2) the Basic Science Research Program, and (3) the Multicenter National Prostate Cancer Database to encompass its clinical research work with participating military medical centers. The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) is a nonprofit organization dedicated to advancing military medicine. We serve military, medical, academic and government clients by administering, managing and supporting preeminent scientific programs that benefit members of the armed forces and civilians alike. Since its founding in 1983, HJF has served as a vital link between the military medical community and its federal and private partners. HJF's support and administrative capabilities allow military medical researchers and clinicians to maintain their scientific focus and accomplish their research goals.