US Executive Director, Early Assets

Introduction to role: Are you ready to turn ideas into life-changing medicines? At AstraZeneca, scientific innovation drives everything we do to address unmet patient needs. In this role, reporting directly to the US Executive Director Early Assets, the US Executive Director, Early Assets will lead the development of bold US medical strategies for our early pipeline, provide scientific input to cross-functional teams, and build an influential external network across US disease areas where AstraZeneca has pipeline programs. This is a chance to develop, design, and influence across a complex matrix so that US perspectives are embedded in global development plans and future launches. Want to be at the point where early science meets real-world impact?

What You'll Do:

Lead the US medical strategy for early pipeline assets, ensuring alignment with portfolio priorities, disease area strategy, and long-term business objectives. Act as the internal US medical authority for emerging assets, providing authoritative mentorship on scientific, clinical, and real-world considerations across cardiovascular, metabolism, and related therapeutic areas. Partner closely with global medical and R D teams to shape robust translational and early clinical development plans, integrating US medical insights, health system realities, and real-world data opportunities. Influence study builds and development strategies by collaborating with Clinical, Global Commercial, and Medical teams on endpoints, comparators, inclusion/exclusion criteria, and real-world evidence plans that enable future US access, labeling, and promotion. Craft clear and compelling scientific narratives that differentiate early assets, support value propositions, and underpin impactful launch and lifecycle strategies. Drive evidence generation plans across the product lifecycle, including clinical trials and real-world evidence initiatives that support practice change and guideline evolution in the US. Build and coordinate comprehensive external engagement strategies with US authorities, professional societies, policy influencers, and patient groups to inform development plans and accelerate adoption of innovation. Play a key role in medical advisory boards and scientific exchanges, ensuring high-quality insight generation that shapes both global and US strategies. Build and nurture a strong external network across all relevant programs and disease areas, positioning AstraZeneca as a trusted scientific partner in obesity/weight management, cardiovascular disease, metabolism, and adjacent fields. Champion cross-functional collaboration within a complex matrix environment, connecting stakeholders across Medical, R D, Commercial, Market Access, HEOR, and Policy to drive coordinated decision-making. Identify and act on opportunities to accelerate early asset development, de-risk key decisions, and prepare the US market for first-in-class or best-in-class launches.

Essential Skills/Experience:

Sophisticated Scientific Degree (MBBS, PharmD, PhD, or MD) or international equivalent A minimum of 5 years of experience in the pharmaceutical industry (medical, marketing, R D, market access roles), or working in a relevant health system setting (clinical, pharmacy, pathway design etc.) Deep medical, clinical or scientific expertise in CV and metabolism (especially in obesity/weight management). Experience/knowledge in immunology and/or cell therapy also preferred. Experienced business leader able to deliver results in a complex matrix environment US regulatory strategy knowledge including product approval, label requirements/negotiation Validated ability to build internal/external networks and to collaborate internally/externally Substantial evidence generation/data expertise, e.g. clinical trial experience (conducted Ph2, Ph3 or Ph4 studies), and/or substantial RWE experience Desirable Skills/Experience Global and/or R D experience, or consistent record of supporting early asset or first-in-class product development Relevant experience beyond medical affairs (e.g. in a marketing/R D/market access role) When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. At AstraZeneca, medical leaders sit at the intersection of cutting-edge science and real-world healthcare practice, shaping decisions from early R D investment through to evidence that changes clinical guidelines. The environment is fast-paced and collaborative, with close partnerships across Research & Development, Commercial, Market Access and external experts to turn promising early assets into medicines that matter. Curiosity is encouraged, new ideas are acted on quickly, and there is genuine scope to grow skills across therapy areas, functions and geographies as our pipeline expands. Working here means contributing directly to advances that improve patients' lives while developing a career with breadth, depth and continuous learning. If this role matches your experience and ambition, apply now to help shape the future of early medicines development at AstraZeneca. The annual base pay for this position ranges from $331,874 to $497,810 Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 28-Apr-2026 Closing Date 07-May-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We're curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We're driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you'll do work that has the potential to change your life and improve countless others. And, together with your team, you'll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.