Senior Director, Evidence Generation

Job Description:

The Senior Director, Evidence Generation will serve as the lead of real-world evidence generation strategy, execution, and partnership across the Xeris commercial and investigational pipeline reporting into the VP, Medical Affairs. This role is a strategic leader responsible for defining, developing and executing integrated evidence generation strategies that demonstrate clinical, economic, and humanistic value of the company's therapies across the product lifecycle. This position is critical for contributing to product lifecycle management and R D pipeline decisions. This role provides scientific, analytical, and operational leadership for health economics, outcomes research, real-world evidence (RWE), patient-reported outcomes (PRO), and comparative effectiveness research initiatives that support market access, reimbursement, regulatory, and clinical decision-making. The Senior Director partners cross-functionally with Medical Affairs, Clinical Development, Biostatistics, Market Access, Regulatory Affairs, Commercial, Business Development, and external stakeholders to generate high-quality evidence that informs healthcare decision-makers, payers, providers, patients, and policymakers. This role will help define the vision, structure, and capabilities of the Evidence Generation team as this function evolves. Essential Job Functions Develop and execute integrated HEOR and evidence generation strategies and plans across product lifecycle, including portfolio planning and life cycle management activities Foster a culture of scientific excellence, innovation, collaboration, and continuous improvement. In partnership with Medical Affairs Leadership, define the vision, structure, and capabilities of the Evidence Generation team for future state. Identify evidence gaps and prioritize studies to support payer, provider, institution and patient-level decision-making Provide HEOR input into clinical development programs, including endpoint selection and evidence planning. Lead development of economic models, budget impact analyses, cost-effectiveness studies, and value dossiers Oversee generation of comparative effectiveness and burden-of-illness evidence Guide development of patient-reported outcomes and health-related quality-of-life research programs Ensure methodological rigor and scientific validity across all real-world evidence initiatives Ensures projects, initiatives, analyses align with medical and brand strategic plans with cross functional alignment Evaluate and acquire novel data sources to generate actionable evidence Oversee retrospective database analyses, pragmatic trials, and outcomes research studies in partnership with Medical and Scientific Leads and/or external subject matter experts Establish and maintain relationships with external researchers, healthcare decision-makers, and evidence-generation partners. Responsible for strategic and timely communications on execution of plans internally and externally (as identified) leading to successful completion and data disclosure Executive presence and ability to engage with senior leaders in a cross functional setting. Oversee external vendors and partnerships to ensure high quality, high impact, robust outputs Collaborate with Publications and Medical Communications on timely communication and publication of research Ensures HEOR book of work integrates and aligns with the product strategic plans from matrix teams as well as commercial interests. Provides updates on execution of plans to product as well as functional management, owns, then shares project execution decisions. In the development of product strategic plans, he/she liaises with other members of the product team to generate innovative ideas and create buy-in strategies Accountable for end-to-end delivery of HEOR book of work under their remit, from strategy development to content pull through Accountable to ensuring strong partnership with all relevant

HEOR COE

functions to ensure a comprehensive HEOR voice is represented in cross-functional meetings Executive presence and ability to engage with senior leaders in a cross functional setting. Ensures HEOR book of work integrates and aligns with the product strategic plans from matrix teams as well as commercial interests. Provides updates on execution of plans to product as well as functional management, owns, then shares project execution decisions. In the development of product strategic plans, he/she liaises with other members of the product team to generate innovative ideas and create buy-in to strategies Accountable for end-to-end delivery of HEOR book of work under their remit, from strategy development to content pull through Accountable to ensuring strong partnership with all relevant

HEOR COE

functions to ensure a comprehensive HEOR voice is represented in cross-functional meetings Executive presence and ability to engage with senior leaders in a cross functional setting. Skills and Qualifications PhD, DrPH, ScD, PharmD, MD, or equivalent advanced degree in Health Economics, Outcomes Research, Epidemiology, Public Health, Health Services Research, Biostatistics, Pharmacy, Medicine, or related discipline. Demonstrated expertise both scientific and technical in health economics, pharmacoepidemiology, biostatistics, or real-world evidence research. 12+ years of experience in HEOR, outcomes research, epidemiology, market access, or evidence generation within the pharmaceutical, biotechnology, consulting, or healthcare industry. Experience supporting payer engagement & reimbursement strategy Track record of scientific publications and presentations in peer-reviewed journals and major congresses.

Technical competencies:

Health economics modeling and value assessment Real-world evidence strategy and execution Comparative effectiveness research Patient-reported outcomes and quality-of-life measurement Epidemiology and observational study design Market access and reimbursement strategy Health technology assessment requirements Evidence synthesis and systematic literature reviews Data analytics and healthcare databases Scientific communications and publication planning

Competencies:

Teamwork & Collaboration, Attention to Detail, Self-Starter, Analytical skills, Negotiation skills, Problem Solving, Organizational skills, Project Management, Adaptability, Professionalism, Written and Verbal Communications, Presentation skills, Strategic Leadership, Functional Leadership, Strategic Vision Working Conditions Position may require periodic evening and weekend work, as necessary to fulfill obligations. Periodic overnight travel. Position may require both vehicle and air travel. This is a hybrid role based in Xeris' Chicago office and requires a minimum of three days per week in the office. On-site requirement may change at management's discretion. The anticipated base salary range for this position is $252,000-$337,000 #

LI-HYBRID

Direct Employers Posting:

Chicago, IL. Xeris Pharmaceuticals, Inc. (the "Company") is an equal opportunity employer and does not discriminate based on race, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, veteran status, genetics or any other characteristic protected by law. All qualified candidates are given equal opportunity and the Company's employment selection decisions are based solely on job-related factors.

NOTE:

This job description is not intended to be all-inclusive. The employee may be required to perform other related duties as needed to meet the ongoing needs of the Company. The level of the position will be determined based on the selected candidate's qualifications and experience. Final determination of the actual base salary offered depends on several factors, including but not limited to the candidate's skills, experience, education, location, and business needs. Employees are eligible for equity or long-term incentive awards, where applicable. Field Sales role employees are eligible for a quarterly commission structure. Non-Sales role employees are eligible for an annual bonus. The Company also offers a comprehensive benefits package that includes additional elements such as paid time off benefits, various health, vision, and dental insurance options, 401(k) retirement benefits and more for eligible employees. Details about these and other offerings will be provided at the time a conditional offer of employment is made. Candidates are always welcome to inquire about our compensation and benefits package during the interview process. Individuals hired as temporary employees, interns, and preceptors are not eligible for commissions, bonuses, and/or long-term incentive or equity awards. Eligibility for other benefits will be based on plan documents. Accessibility & Reasonable Accommodations If, because of a medical condition or disability, you require a reasonable accommodation or assistance to complete any part of the application process, please send an e-mail to recruiting@xerispharma.com and identify the type of accommodation or assistance you are requesting. Please include the job requisition number in your message. Please note if your request is not for this stated purpose, you will not receive a response to your email. Do not include any medical or health information in this email. Xeris participates in E-Verify. E-Verify Participation Poster EEO is the Law EEO is the Law EEO is the Law Supplement EEO is the Law Supplement Pay Transparency Nondiscrimination Provision Pay Transparency Nondiscrimination Provision Xeris is a growth-oriented biopharmaceutical company committed to improving patient lives by developing and commercializing innovative products across a range of therapies. Xeris is headquartered in Chicago, Illinois and has a strong foundation built on proprietary formulation technologies and deep expertise in clinical development and commercialization. Recruitment Fraud Notice Please be cautious of scam recruitment offers claiming to be from Xeris. Xeris will never request personal or financial information, payment, or fees at any stage of the recruitment process. All legitimate recruiting communications will come from a @xerispharma.com email address. If you receive an unsolicited employment offer or are asked to provide personal information by someone claiming to represent Xeris, do not respond, click links, or open attachments, and report the incident to local law enforcement. Accessibility & Reasonable Accommodations If, because of a medical condition or disability, you require a reasonable accommodation or assistance to complete any part of the application process, please send an e-mail to recruiting@xerispharma.com and identify the type of accommodation or assistance you are requesting. Please include the job requisition number in your message. Please note if your request is not for this stated purpose, you will not receive a response to your email. Do not include any medical or health information in this email. Equal Employment Opportunity Xeris Pharmaceuticals, Inc. (the "Company") is an equal opportunity employer and does not discriminate based on race, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, veteran status, genetics or any other characteristic protected by law. All qualified candidates are given equal opportunity and the Company's employment selection decisions are based solely on job-related factors.