Principal Scientist AI-Powered Discovery for Neurodegeneration

Principal Scientist AI-Powered Discovery for Neurodegeneration Employer Sanofi Location Cambridge, Massachusetts Start date Jun 16, 2026 View more categories View less categories Discipline Science/R D , Biotechnology , Neuroscience Required Education Bachelors Degree Position Type Full time Hotbed Genetown Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job

Job Details Company Job Details Job Title :

Principal Scientist, Neurology Research, Cambridge MA Location:

Cambridge, MA About the Job As a Principal Scientist within the Neurology Research Team you will lead machine learning/AI based discovery efforts to advance research programs focused on Alzheimers, Parkinsons, ALS/FTD, and Multiple Sclerosis. You will join a team to lead the analyses of large scale public and internal data sets from human brain tissue single cell and spatial omics (rna, protein and lipids), fluid proteogenomic biomarkers (CSF and plasma), and functional screening (CRISPR) in human disease relevant cell models. You will help uncover causal molecular and cellular mechanisms of disease by employing state-of the art Machine Learning/AI methods on the above data sets to accelerate new target and biomarker discovery efforts. Join the engine of Sanofis mission - where deep neuroscience meets bold, AI-powered research. In R D, youll drive breakthroughs that could turn the impossible into possible for millions

About Sanofi:

Were an R D-driven, AI-powered biopharma company committed to improving peoples lives and delivering compelling growth. Our deep understanding of the immune system and innovative pipeline enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve peoples lives. Main responsibilities Leading and implementing the full-scale analyses, integration and harmonization of omics data sets to deliver a decision-grade resource for neurology TA. Integrate single-cell genomics with plasma and CSF proteomics and clinical outcomes from public and in-house datasets to identify cell state shifts and molecular features associated with disease progression, contributing to refining patient selection criteria for future trial designs. Champion the 'Everyday AI' initiative to establish a baseline of AI literacy across the Neurology TA. Lead cross-functional upskilling programs to ensure universal digital fluency, accelerating productivity by integrating AI tools into daily non-technical and technical workflows. Lead authorship of impactful scientific publications. About you

Education:

Bachelor's degree in Biology, Biochemistry, Bioengineering, Computer Science, Mathematics, Statistics, Physics, Neuroscience, or related quantitative/life science fields, followed by a Ph.D. in Computational Biology, Bioinformatics, Neuroscience, or related fields.

Basic Qualifications:

Minimum 4+ years of post-PhD experience in the biotech industry or academic institution, with a strong track record in computational biology applied to neurodegenerative diseases. Deep expertise in analyzing large-scale datasets including multi-omics, single-cell genomics, and spatial transcriptomics. Proven experience in neurodegenerative disease research, specifically Alzheimer's disease (AD), Parkinson's disease (PD), Multiple Sclerosis (MS), and ALS/FTD.

Human Brain Genomics Expert:

Demonstrated experience analyzing human brain single-cell genomics datasets and/or

CSF/PBMC

atlases.

Proteomic Analysis:

Proven ability to analyze proteomic datasets from neurodegenerative disease patient tissue or biofluids.

Model Systems Knowledge:

Deep understanding of omics analyses in mouse and cellular models of neurodegenerative disease.

Advanced Analytical Workflows:

Expertise in developing analytical workflows for discovering and quantifying cryptic splices in scRNAseq, long-read, and spatial transcriptomics datasets.

AI/ML Proficiency:

Proven experience using AI/ML models to explore cell gene regulatory landscapes of disease-associated cell states from single-cell transcriptomic, ATACseq, and cryptic splicing datasets.

Foundational Knowledge:

Broad technical skills and deep foundational knowledge of neuroscience, bioinformatics, pharmacology, life science, and statistics.

Publication Record:

Track record of impactful scientific achievement as demonstrated by co-first/lead as well as contributing author publications. Excellent communication skills and evidence of success in complex, multidisciplinary environments are required.

Preferred Qualifications:

Highly motivated and driven with strong collaborative skills. Excels working in collaborative teams with diverse expertise. Ability to relate computational analyses with clarity and precision to non-computational stakeholders. Strong problem-solving skills and ability to work independently in a fast-paced research environment. Why Choose Us Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether its through a promotion or lateral move, at home or internationally. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks gender-neutral parental leave. Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. Help improve the lives of millions of people globally by making drug development quicker and more effective. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. Why Choose Us Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether its through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks gender-neutral parental leave. Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. Help improve the lives of millions of people globally by making drug development quicker and more effective. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SA #LI-SA #vhd #LI-Onsite All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here. Company Pursue Progress. Discover Extraordinary. Science has been our calling from the beginning. Sanofi's heritage of turning the impossible into the possible stretches back to the 19th century — a rich history of healthcare innovation built by diverse companies united by one shared purpose. More than 150 years later, that spirit lives in everything we do and every person we serve — from the patients who take our medicines, to the healthcare professionals who trust us, to the 83,000+ employees and communities around the world who make it all possible. And today, we're writing the next chapter of that legacy. We are an R D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Better is out there. Better medications, better outcomes, better science. And it all starts with people like you — from different backgrounds, in different locations, doing different roles — united by a single mission: we chase the miracles of science to improve people's lives. Take the most important step in your career and help us change the lives of patients, families, and communities for the better. Company info Location Cambridge Massachusetts United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert