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Senior Scientist, Antibody Conjugation Employer Nurix Therapeutics Location Brisbane, CA Start date Sep 14, 2026 View more categories View less categories Discipline Science/R D , Biotechnology Required Education Bachelors Degree Position Type Full time Hotbed Biotech Bay Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Send job Job Details Company Job Details Senior Scientist, Antibody ConjugationAbout the Role We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies. This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material. What You'll Do Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies. Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms. Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines. Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise. Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently. Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed. Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline. Who You Are A team player who works well across disciplines (chemistry, analytical, protein biochemistry, automation/engineering) and communicates clearly with both scientists and technical staff.

Results-oriented:

you drive a method from first attempt to a robust, transferable protocol, and you personally deliver material when a study needs it. Comfortable owning a technical area with real autonomy in a growing capability area. Qualifications PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered. Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.

Experience purifying and characterizing conjugates:

FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis. Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team. Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization Why This Role You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled — with direct visibility to program leadership and a fast path from method development to real studies

Salary Range:

$174,900 - $185,200 plus bonus and equity Fit with Nurix Culture and Values Strong team orientation; highly collaborative Solutions and results-oriented focus Hands-on approach; resourceful and open to diverse points of view We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US. Company Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info Website https:

//www.nurixtx.com/ Phone 415-660-5320 Location 1700 Owens Street Suite 205 San Francisco California 94158 United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. Create alert Similar jobs Senior Scientist - Protein Expression Sciences Tarrytown, New York Senior RNA Chemist RNA Therapeutics Thousand Oaks, California Order Management Associate Scientist Piscataway, New Jersey