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New Senior Director, Toxocology Bedford, Massachusetts, United States Apply About Stoke:

Stoke Therapeutics (

Nasdaq:

STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke's initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke's proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/

Position Purpose:

Stoke is seeking a highly motivated and experienced senior Toxicologist to join a company pioneering genetic disease treatments. The successful candidate will play a key role at Stoke Therapeutics leading the nonclinical toxicology work in support of our drug discovery and clinical programs and will have hands-on responsibility for preparation of preclinical safety data packages for clinical development and product registration. The ideal candidate will have extensive experience with the design, execution and interpretation of in vitro and in vivo toxicology studies. The candidate will be responsible for coordinating and interfacing with CROs to undertake these studies, and will be accountable for the review, analysis and reporting of the safety pharmacology and toxicology data. This leader will need to work across a multi-disciplinary team to advance programs through the pipeline. The successful candidate will have extensive experience of reviewing and creating regulatory documents (INDs, CTAs, NDAs etc.) and interacting successfully with global regulatory agencies. This position currently reports to the Chief Scientific Officer.

Key Responsibilities:

Provide leadership, technical oversight, and guidance for all nonclinical safety studies conducted to support Stoke Therapeutics discovery and development programs to ensure delivery of a high-quality safety package for development and registration. Lead the design and direct management for nonclinical safety studies, including the evaluation and interpretation of safety pharmacology, toxicology and toxicokinetic information. Manage the preparation and presentation of nonclinical safety data for project teams, regulatory agencies, and executive management. Prepare toxicology sections in regulatory documents (IND, CTA, NDA, IB and annual reports) and aid in preparation of responses to regulatory agencies. Develop an optimal CRO network to support nonclinical safety studies and identify, manage external CROs to conduct appropriate studies. Manage toxicology goals, priorities, resource requirements, budget, and timelines in coordination with program teams. Collaborate effectively with Discovery Research, DMPK, Chemistry/CMC functions as well as with key Clinical and Regulatory stakeholders. Regularly assess the evolving oligonucleotide drug development field to ensure awareness and implementation of industry- and regulatory agency-aligned best practice for safety studies. Represent Stoke Therapeutics toxicology function with key external stakeholders, partners and global regulatory agencies.

Required Skills & Experience:

Ph.D. in Pharmacology, Toxicology, or a relevant discipline or DVM is required A Diplomate, American Board of Toxicology (DABT) or equivalent is preferred At least seven years of industry experience in Toxicology or a relevant field Track record successfully supporting therapeutic programs from target identification through development (and ideally registration) with small molecules and/or oligonucleotides Experience in all aspects of toxicology including general, developmental and reproductive toxicology, carcinogenicity, toxicokinetics, and safety pharmacology Knowledge of FDA GLP and ICH guidelines Experience authoring regulatory documents and interacting with FDA, EU and other global regulatory agencies. Effective management of external collaborations and service providers (CROs) and ability to bring pragmatic business-minded approach to balancing internal and external capabilities and workflow Familiarity with oligonucleotides or messenger RNA therapeutics is preferred Experience with drug development in the CNS and/or eye is preferred Strong organizational, collaboration and recordkeeping skills are required Strong presentational skills to be able to communicate to both internal and external audiences, including both technical and management audiences Highly motivated cross-functional team player with the ability to work in a fast-paced environment. Ability to provide novel, innovative solutions to challenging problems. Location(s): Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This is a hybrid position.

Travel:

This position will require approximately 10% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $285,000 - $320,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates:

Please visit Stoke's website to learn more and apply directly to the position listed on our

Career Center:

https://www.stoketherapeutics.com/careers/ For more information, visit https://www.stoketherapeutics.com/. All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify. Create a Job Alert Interested in building your career at Stoke Therapeutics? Get future opportunities sent straight to your email. Create alert Apply for this job

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.. I certify that I have read and understand the applicant instructions included with this application and that the answers given by me to the foregoing questions and statements made by me are complete and true to the best of my knowledge and belief. I certify that I understand that Stoke Therapeutics participates in E-Verify and will provide the federal government with my Form I-9 information to confirm that I am authorized to work in the United States once I have accepted a job offer and completed the Form I-9. I understand that any false information, omissions or misrepresentations of facts called for in this application, whether on this document or not, may result in rejection of my application or discharge at any time during my employment. I understand that this application form is intended for use in evaluating my qualifications for employment and that this application is not an offer of employment. I further understand that if hired, my employment will be considered \"at-will\" and that my employment may be terminated for any reason, with or without cause or notice, at any time by me or the Company and that this application is not intended to constitute a contract of continued employment. Are you a referral from a current Stoke Therapeutics employee?

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.. Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Stoke Therapeutics's Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law. Gender Select... Are you Hispanic/Latino? Select... Race & Ethnicity Definitions If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows: A \"disabled veteran\" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A \"recently separated veteran\" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An \"active duty wartime or campaign badge veteran\" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. 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Senior Director, Toxocology

Senior Scientist, In Vivo Pharmacology