Global Program Operations Head (GPOH)

Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. Summary We are seeking a Global Program Operations Head (GPOH), reporting into the Vice President, Clinical Operations, to lead the strategic and operational execution of a portfolio of clinical trials within a designated disease area. This role partners cross-functionally with Clinical, Medical, Regulatory, and Operational Excellence to ensure programs are aligned with corporate goals, regulatory requirements, and operational feasibility. You will drive program-level strategy, oversee trial execution, and manage Contract Research Organizations (CROs) and external vendors, ensuring delivery against timelines, budgets, and quality expectations. Additionally, you will lead and develop a high-performing clinical operations team while supporting governance, risk management, and inspection readiness in a fast-paced biotech environment. Your Role Oversee the strategic and operational execution of a portfolio of clinical trials within a designated disease area Ensure alignment with corporate goals and regulatory standards Represent Global Clinical Operations in Global Program Teams (GPTs) and sub-teams, contributing to program-level strategy and operational planning Collaborate with Medical and Regulatory Directors to ensure clinical strategies are scientifically sound, meet regulatory requirements, and are operationally feasible Partner with Operational Excellence & Clinical Compliance to align on risk assessment, trial- and site management metrics, KPIs, and KRIs Define and implement outsourcing strategies in partnership with the VP of Global Clinical Operations and Head of Clinical Sourcing & Contracting Lead the selection, negotiation, contracting, and performance oversight of CROs and external vendors Monitor trial progress and key deliverables, guiding Clinical Trial Teams (CTTs) in execution planning, issue resolution, and risk mitigation Manage program and trial budgets, ensuring accurate forecasting, cost control, and financial accountability Track CRO/ vendor performance using metrics, KPIs, KRIs and participate in governance meetings to address escalated issues and drive continuous improvement Provide regular updates on trial progress to internal governance bodies, including GPT and Executive Leadership Team Support inspection readiness activities and represent the organization during Health Authority inspections Provide leadership, coaching, and performance management to Clinical Trial Leaders (CTLs), Clinical Contract Managers (CTMs), Clinical Trial Specialists (CTSs), and Site Management Leader (SMLs) Set clear objectives, deliver ongoing feedback, and develop tailored development plans to support team growth and capability building Oversee hiring, onboarding, and training of new team members, fostering a culture of operational excellence and continuous learning What You Bring 12+ years of trial management experience with 7+ years in leadership position Bachelor's degree in Life Sciences, Pharmacy or related field (required). Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred). Significant experience working in global clinical development organization Experience in Oncology development (preferred) Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections Significant experience in outsourcing and oversight Expert knowledge in

ICH-GCP, FDA

guidelines, EU CTR and other relevant guidelines Expert knowledge in financial planning, tracking, and reporting Expert knowledge in risk assessment and management on program and trial-level Executive presence and strategic thinking on corporate-, program-, and trial-level Strong decision‑making and sound judgment Strong leadership and interpersonal skills High credibility with senior leadership Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs Willingness to travel, as required (typically 10-20%) #LI-Hybrid We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status