Director, Toxicology

Pliant Therapeutics is a clinical-stage biopharmaceutical company and leader in the discovery and development of novel integrin-based therapeutics. Based in South San Francisco, California, Pliant was founded in 2015 to develop therapeutics to modulate specific pathways upregulated or dysfunctional in certain diseases. Our approach involves developing novel integrin-based therapeutics to treat solid tumors and other diseases. Integrins are a crucial link between a cell's internal structure and its external environment and function in cell signaling, regulation and adhesion as well as wound healing and immune response. Founded by a team of world-renowned researchers from the University of California, San Francisco, this group discovered key insights into the integrin biology and developed small molecule therapeutics to target this devastating disease process. Launched in 2016 by Third Rock Ventures, a leading healthcare venture capital firm, Pliant has developed an industry-leading proprietary library of over 15,000 integrins that serve as a key driver to its portfolio. We believe our platform may be broadly applicable across multiple disease areas including delivery of drug payloads to cells utilizing integrin receptor-binding molecules as tissue-specific delivery and internalization mechanisms. Currently, Pliant is conducting a Phase 1 study of PLN-101095, a small molecule, dual-selective inhibitor of αvß8 and αvß1 integrins, that has shown encouraging clinical activity in the development of a treatment of immune checkpoint resistant solid tumors. Description The Director of Toxicology is a strategic and hands-on scientific leader responsible for shaping and executing nonclinical safety strategies across the discovery and development portfolio. Reporting to the Vice President of Nonclinical Development, this individual serves as the company's nonclinical safety expert - driving the design, execution, and interpretation of toxicology and safety pharmacology programs from early research through regulatory submission. This role provides strong scientific and intellectual leadership across cross-functional teams, partners closely with internal stakeholders and external vendors, and represents nonclinical safety in interactions with global regulatory authorities. The ideal candidate is a collaborative, self-directed leader with deep industry experience across all stages of drug development, and a proven track record of U.S. and ex-U.S. regulatory submissions. Responsibilities Designs and oversees non-GLP and GLP nonclinical safety programs to advance Pliant's pipeline of small and large molecule therapeutics for global submissions Develops and implements target de-risking and screening strategies in discovery teams to support safety lead optimization efforts Leads investigative efforts into mechanisms of toxicity as needed Serves as the nonclinical safety subject matter expert, contributing to cross-functional program strategy and decision-making Collaborates closely with internal cross-functional groups such as Pharmacology, ADME-PK, BA, CMC, Regulatory Affairs, Clinical Development, and Project Management Analyzes, interprets, summarizes, and presents nonclinical safety data to internal teams and senior leadership Authors and reviews safety pharmacology and toxicology sections of global regulatory documents for IND and post-IND stage programs and acts as a nonclinical point of contact for any information requests Represents the organization in interactions with global health authorities, including preparation for and participation in agency meetings Authors SOPs in collaboration with QA and in compliance with US and

OECD GLP

guidelines Provides scientific oversight of external CROs and vendors, ensuring high quality, timely, and cost-effective safety assessment Authors publications and presents externally at scientific meetings, as corporate needs arise Qualifications To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, abilities, and prior experience required. PhD in Toxicology, Biology, Pharmacology or related scientific discipline; Board certification (DABT) required 10+ years of relevant industry experience in nonclinical safety evaluation across drug discovery and development Demonstrated expertise in small and large molecule Discovery/Regulatory Safety Assessment and regulatory toxicology guidelines, requirements, and standards (GLP, OECD, ICH, CTD, etc.) Proven ability to develop and implement nonclinical strategies that support clinical progression and regulatory approval Strong scientific judgement, critical thinking, and problem-solving capabilities Excellent written and verbal communication skills, including regulatory document authorship and executive-level presentation experience Demonstrated ability to work effectively and collaboratively on cross-functional project teams Ability to thrive in a fast-paced biotech environment, balancing strategic leadership with operational execution and timely decision-making How you work Dare to

Succeed:

Applies scientific curiosity and discipline to challenge assumptions, proactively identify safety risks, and develop innovative toxicology strategies that enable confident decision-making across discovery and development Make an

Impact:

Demonstrates strong ownership of nonclinical safety strategy and execution, driving programs forward with urgency while ensuring high-quality, regulatory-ready results that directly influence pipeline advancement

One Pliant:

Builds strong, trust-based partnerships across functions and with external collaborators, integrating diverse scientific perspectives to align on program strategy and deliver results as a unified team The annual base salary for this role is $232,000 - $256,000. Individual pay may vary based on additional factors, including, and without limitation job-related skills, experience, work location and relevant education or training. Pliant's compensation package also includes benefits, equity, and annual target bonus for fulltime positions. To understand how Pliant complies with and manages your personal information with respect to the California Consumer Privacy Act, please visit https://pliantrx.com/ccpa-applicant-and-staff-privacy-notice/ .

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