Type:

full-time

Job Description:

Scientist, Process Sciences Location:

Cambridge, MA Contract Duration:

12 Months with opportunity to extend

Pay Rate:

Up to $56.00/hour or about $114,000 a year

Schedule:

Monday-Friday, standard business hours Position Overview We are seeking a Scientist, Process Sciences to support the development, characterization, optimization, and scale-up of oligonucleotide manufacturing processes . This is a highly hands-on, laboratory-based role focused on drug substance development, process development, process characterization, and manufacturing support . The Scientist will independently execute experiments, lead technical projects, analyze experimental data, and prepare technical reports and manufacturing documentation. This individual will work closely with cross-functional teams, including Analytical Development, Manufacturing, Quality Assurance (QA), Quality Control (QC), and external CMO/CRO partners , to support process development, transfer, optimization, and manufacturing of oligonucleotide drug candidates. This position is 100% onsite at the in Cambridge, MA and requires daily laboratory work. Key Responsibilities Contribute to the development, optimization, characterization, and scale-up of oligonucleotide manufacturing processes . Perform hands-on laboratory experiments supporting drug substance and API process development . Independently design, plan, execute, and document experiments. Support process and product characterization of oligonucleotides and small-molecule APIs. Utilize HPLC and other analytical techniques to evaluate processes and characterize products. Apply chemistry and/or chemical engineering principles to troubleshoot processes, interpret experimental results, and recommend improvements. Support the management and optimization of both in-house and contract manufacturing processes . Lead or contribute to technical projects related to process development and manufacturing. Support process transfer and process optimization activities with internal manufacturing teams and external CMO/CRO partners. Author and review technical protocols, experimental reports, development reports, and manufacturing documentation . Prepare and review documentation in accordance with applicable regulatory requirements and internal procedures. Collaborate closely with Analytical Development, Manufacturing, QA, QC, and external manufacturing partners . Participate in technical and scientific discussions and present project progress and experimental findings at internal and external meetings. Work safely with hazardous laboratory chemicals , including acids, bases, and chemicals commonly used in oligonucleotide development. Required Qualifications Master's degree in Chemistry, Chemical Engineering, Biochemical Engineering, or a related scientific/engineering discipline with approximately 3+ years of relevant industry experience , OR PhD in Chemistry, Chemical Engineering, Biochemical Engineering, or a related discipline with approximately 1+ year of relevant postdoctoral or industry experience . Hands-on HPLC experience is required. Strong background in chemistry and/or chemical engineering principles . Hands-on experience with process development and analytical methods used for process and product characterization . Demonstrated ability to independently plan and execute laboratory experiments. Experience analyzing and interpreting experimental data and applying findings to process development or optimization. Experience authoring technical reports, protocols, and/or manufacturing documentation . Strong analytical, troubleshooting, and problem-solving skills. Excellent organizational, written, and verbal communication skills. Ability to work effectively in a fast-paced, deadline-driven laboratory environment . Must be comfortable working with hazardous chemicals, including acids and bases , on a routine basis. Preferred Qualifications Approximately 3+ years of oligonucleotide therapeutics process research and development experience . Experience with oligonucleotide chemistry, synthesis, purification, process development, or manufacturing . Demonstrated experience designing and developing practical manufacturing processes for oligonucleotides and/or small molecules . Experience with drug substance/API process development and scale-up . Experience supporting technology/process transfer to manufacturing or external CMOs . UNICORN software experience is a plus. Veeva experience is preferred. Team & Work Environment The immediate Process Sciences team consists of approximately 6 people , with a broader department of approximately 20 employees . This is an individual contributor position , although candidates with more senior experience are welcome to apply if they are comfortable remaining in a hands-on individual contributor role. The position requires working onsite in the laboratory five days per week . The standard schedule is Monday through Friday during normal business hours, with no regular weekend work . 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