Job Description About the role:

You will lead the Biotherapeutics Downstream Process Development function, directing a multidisciplinary team of scientists and engineers who develop and characterize purification processes for biotherapeutics across early- and late-stage assets. You will oversee internal development work and external partners, including contract development and manufacturing organizations, to ensure project deliverables, timelines, and quality expectations are met. You will manage preparation and approval of CMC sections for global regulatory submissions and lead responses to regulatory questions. You will drive rapid, phase-appropriate early-stage development toward Investigational New Drug (IND) applications using platform strategies, maintain a strong external presence to bring scientific advances and efficiency into the organization, and contribute to Pharmaceutical Sciences-wide initiatives that shape development strategy and long-term technical priorities.

How you will contribute:

Lead and develop a multidisciplinary team responsible for purification process development and characterization for monoclonal antibodies, fusion proteins, and related biologic modalities across discovery, preclinical, clinical, and commercial phases. Serve on the biotherapeutics process development leadership team to set technical strategy, coordinate priorities across programs, and support decisions that advance the portfolio. Work closely with upstream, analytical, and drug product development organizations to align activities, reduce handoffs, and streamline process development to accelerate time to market. Contribute to Pharmaceutical Sciences-wide initiatives, collaborating with peers across development, manufacturing, quality, and regulatory groups to drive standardization, platform improvements, and capability building. Oversee downstream development activities conducted internally and at contract development and manufacturing organizations to ensure project deliverables, timelines, and transfer readiness. Manage preparation, review, and approval of chemistry, manufacturing, and controls sections for global regulatory submissions and coordinate timely responses to agency questions. Drive rapid, phase-appropriate development to Investigational New Drug applications using platform process strategies and risk-based decision making. Lead technology transfer, scale-up, process characterization, and validation efforts to enable reliable manufacture at scale. Ensure adherence to Good Manufacturing Practices and quality systems across internal teams and external partners. Cultivate and leverage external scientific and industry networks, partnerships, and vendors to introduce new approaches, efficiencies, and best practices. Mentor and develop leaders and scientists within the team and influence partners and senior leadership on downstream strategy.

Skills and qualifications:

Ten or more years of industry experience in biologics downstream process development with progressive leadership responsibility; advanced degree in biochemical engineering, chemical engineering, biochemistry, chemistry, or a related discipline required; doctoral degree preferred. Demonstrated experience collaborating with partner organizations to streamline development activities and shorten time to market. Demonstrated experience preparing and approving chemistry, manufacturing, and controls sections for global regulatory submissions and responding to regulatory agency queries. Proven track record managing external development and manufacturing partners, including contract development and manufacturing organizations, and overseeing technology transfer and scale-up. Deep technical expertise in downstream purification platform technologies, including chromatography and filtration, process characterization, viral clearance strategy, and product quality attributes. Experience driving early-stage development to IND applications using phase-appropriate, platform-based approaches and risk-based development strategies. Experience serving on process development or biotherapeutics leadership teams and contributing to organization-wide Pharmaceutical Sciences initiatives that enable standardization and capability growth. Strong leadership skills with experience building, mentoring, and retaining high-performing, diverse teams and influencing cross-functional partners and senior leadership. Established external scientific presence and professional network used to source new approaches, collaborations, and efficiency gains. Working knowledge of Good Manufacturing Practices, quality systems, process validation, and regulatory requirements for clinical and commercial biologics manufacturing. Experience using AI-enabled tools (for example, for experiment planning, data analysis, or knowledge search) alongside automation and digital tools to improve process consistency and reproducibility. Clear written and verbal communication skills with experience drafting technical sections of regulatory filings and presenting technical strategy to senior leadership and external audiences. As a strategic leader overseeing multiple functional areas, divisions, or product groups through directors and managers, with global or multi-country-level responsibility. You will shape corporate policies, provide guidance to directors and senior managers, and hold a recognized influential position. Your decisions impact the success of the division, group, company, or corporation, and you may sit on a leadership team, directly influencing the overall business strategy of your area. This position is currently classified as \"hybrid\" in accordance with Takeda's Hybrid and Remote Work policy. Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Lexington, MA U.S.

Base Salary Range:

$212,000.00 - $333,190.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Lexington, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. 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Head of Downstream BioProcess Development