Job Details Company Job Details Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase (BTK), a B-cell signaling protein, and an inhibitor of Casitas B-lineage lymphoma proto-oncogene-B (CBL-B), an E3 ligase that regulates T cell activation. Nurix is also progressing multiple programs through partnership, including an IRAK4 degrader in Phase 1 in partnership with Gilead and a STAT6 degrader in IND enabling studies with Sanofi. Multiple additional wholly owned and partnered programs are at various stages of preclinical development.

Position:

Reporting to the Director, Regulatory Affairs Project Management and Operations, the Senior Manager, Regulatory Operations provides key support to the Nurix Regulatory Affairs department. This position has responsibility for entry-level coordination, review, assembly and archival of regulatory submissions in Veeva RIMS and documents for health authorities (US FDA and global equivalents). The Senior Manager, Regulatory Operations will provide support for multiple regulatory activities, studies, and programs. The individual will have responsibility to understand and implement regulatory guidance and help ensure regulatory compliance for assigned projects. The Senior Manager should have 5 years' experience in Regulatory Affairs or Regulatory Operations. Working knowledge of at least one functional discipline (e.g. Regulatory, Clinical, Nonclinical, Clinical Pharmacology or Chemistry Manufacturing and Controls) and a general knowledge of clinical development preferred. The candidate should have a can-do attitude and experience working in Veeva RIMS. Also, the candidate should be eager to learn regulatory and clinical trial requirements, best practices, and provide support for Regulatory programs and leadership.

Responsibilities:

Under the strategic direction of the SVP of Regulatory Affairs and the Director of Regulatory Affairs PM and Operations, the candidate will support the planning, coordination, tracking and execution of submissions and responses to global regulatory authorities Assist Regulatory team, project teams and Clinical Research Organization (CRO) counterparts in the implementation of regulatory plans, timely delivery, and submission of regulatory documentation Preparation of Regulatory submission documentation (e.g Forms, Cover Letter) as requested Support team with formatting, QC and publishing of submission documents and packages Manage and support Veeva RIMS processes such as HAI, SCP and Archiving Manage authoring and review workflow in Veeva RIMS according to defined timelines Coordinate with regulatory colleagues and cross-functional departments to prepare, compile, review, and submit documents or information necessary to health authorities in accordance with regulations, guidelines or queries IN Veeva RIMS using SCP Maintain archival copies of health authority submissions (e.g., IND, CTA, NDA, and MAA), correspondence and a record of health authority obligations, and commitments Maintain current knowledge of applicable US and global regulations, guidance, and standards for drug development and product registration. Participate in Regulatory Intelligence activities to help inform team members of new applicable guidelines and conduct training sessions on new guidelines/regulations if necessary Participate in kick-off and project-based meetings related to regulatory submissions, strategy, and comment resolution. Be a reliable resource for information following such meetings Follow general instructions from Regulatory management or company leadership for assigned projects while independently planning daily work tasks to complete projects on time. Seek guidance on project/task priorities as needed Communicate important project decisions or challenges to Regulatory leadership Create or contribute to Standard Operating Procedures (SOP), checklists and training Materials for Regulatory department activities Support contracts and Purchase order for the Regulatory Affairs department

Requirements:

Bachelor's Degree in Life Sciences or relevant field Minimum of 5 years' experience working in Regulatory Affairs or Regulatory Operations. Additional experience in the biotechnology or pharmaceutical industry preferred Understanding of the drug development process Proficient knowledge of Veeva RIMS SCP, workflows, archival, reporting… Experienced publisher (DocuBridge, GlobalSubmit, VeevaVault Submission…) Experience successfully supporting critical deliverables while maintaining agreed timelines Demonstrated ability to work effectively with cross-functional teams or collaborative environments. Basic knowledge of 21 CFR and FDA, ICH, GCP, GMP, eCTD, and global guidelines. Previous experience with building electronic submissions in compliance with Health Authority requirements is a plus. Previous experience with maintaining in-house repository for archiving regulatory submissions and Health Authority correspondence in 21 CFR Part 11 compliant system (e.g., Veeva) is a plus. Able to take ownership of a given assignment, proactively consulting other project team members and other department representatives for information or guidance, as necessary.

Superior communication skills:

oral, written, with proven negotiation skills, and strong time-management. Excellent Computer Skills MS Word, Excel, Power Point, Smartsheet and document management software/system, templates. Ability to work on multiple tasks and prioritize tasks to meet company objectives. Strong attention to detail and time management skills are essential. Nurix is located in Brisbane, CA - this is an onsite position. Fit with Nurix Culture and Values Strong team orientation; highly collaborative Solutions and results-oriented focus Hands-on approach; resourceful and open to diverse points of view.

Salary Range:

140K - 162K plus bonus & equity. Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( https://www.nurixtx.com/privacy-policy/ ). Company Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info Website https:

//www.nurixtx.com/ Phone 415-660-5320 Location 1700 Owens Street Suite 205 San Francisco California 94158 United States Share this job Facebook Twitter LinkedIn Apply now Send job Apply now Save job Click to add the job to your shortlist You need to sign in or create an account to save a job. Get job alerts Create a job alert and receive personalized job recommendations straight to your inbox. 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Senior Manager, Regulatory Operations