Senior Director, Safety Science

Senior Director, Safety Science Maze Therapeutics Sales & Business Development South San Francisco, CA, USA USD 283k-346k / year + Equity Posted on Mar 20, 2026 Apply now The Position The Clinical Development team is seeking a Safety Science Director to lead safety science and pharmacovigilance (PV) at Maze. In this highly visible leadership role, you will set the safety strategy across our clinical programs, spanning both common and rare diseases in nephrology and cardiometabolic indications. You will have end-to-end responsibility for safety surveillance, adverse event reporting, risk management, and PV governance, while partnering closely with Clinical Development, Regulatory, Biostatistics, and Clinical Operations. As Maze advances programs from early to late-stage development, you will play a critical role in shaping safety strategy , influencing decision-making, and ensuring patient safety remains central to our work. This position reports to the Head of Clinical Development. The Impact You'll Have In this role, you will combine scientific expertise with leadership and influence to drive results across the organization. Safety Strategy & Oversight Lead safety surveillance and signal identification activities , proactively identifying risks and developing mitigation strategies Provide strategic and operational oversight for case processing , adverse event reporting, and regulatory compliance Oversee the preparation , review , and submission of aggregate safety reports and safety sections of clinical and regulatory documents Author and maint ain safety-related content for clinical protocols, IBs, CSRs, and regulatory submissions Leadership & Collaboration Lead the Safety Management team, fostering a culture of accountability, development, and scientific rigor Partner cross-functionally to develop and execute Safety Management plans aligned with program and corporate objectives Serve as key safety representative in internal governance forums and external discussions with KOLs, advisors, and health authorities. Operational Excellence Provide oversight and strategic direction for outsourced pharmacovigilance activities, including CROs, consultants, and vendors Anticipate operational or compliance risks and proactively remove barriers to program and organizational success As a Director , we also expect you to demonstrate the following

Leadership Competencies:

Leadership Competencies Communication and Influence Builds communication channels across Maze for sharing information Influences Senior Management decisions through persuasive arguments Respectfully addresses differing opinions leading to support of decision Teamwork and Collaboration Champions partnerships and connections across Maze Proactively addresses issues that could result in breakdown of team relationships Spotlights team and individual contributions in public forums Execution and Results Addresses gaps and leverages strengths to get best results Maintains a steadying presence and clarifies priorities during change Anticipates and removes barriers that put functional/corporate goals at risk Develop Others and Self Removes barriers to staff development and empowers them to make their own decisions Stays current on industry trends and keeps direct-reports prepared and responsive What We're Looking For Advanced degree in health sciences (MD/DO, PharmD, PhD) with 4+ years of experience in pharmacovigilance and drug safety. Experience in late-stage clinical development is preferred. Deep k nowledge of global pharmacovigilance regulations and safety requirements . E xperience with medical review of individual case reports, signal detection , trend analysis , and risk mitigation plans Proven experience preparing and reviewing safety reports and responding to regulatory inquiries Demonstrated ability to manage and influence external CRO s and vendor partners A p ositive , adaptab le, and collaborative leadership style with high ethical standards Ability to travel domestically up to 10

• 15 % for internal and external meetings This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week.

About Maze Therapeutics Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company's pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco. Our People Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. Our Core Values Further Together

• Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission. Impact Obsessed
• We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. Stand True
• Our integrity is foundational; it guides us no matter the obstacle. The expected annual salary range for employees located in the San Francisco Bay Area is $283,000
• $346,000 .

Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. #LI-Hybrid Apply now See more open positions at Maze Therapeutics