Lead Technician, Manufacturing

Company DescriptionAxolabs is a business unit of LGC, and a leading provider of

CRO / CDMO

capability to the therapeutic oligonucleotide discovery and development industry. Centred out of LGC's site in Kulmbach, Germany, Axolabs works closely with its customers to assist the identification and development of lead candidates with a broad suite of bioinformatics, biology, chemistry, manufacturing and analytical services that support discovery, pre-clinical and clinical trials and scale-up manufacture. With a track record in Nucleic Acid Therapeutics that traces back more than 20 years, Axolabs provides deep knowledge and expertise in the services it provides, working collaboratively and responsively with its clients to assist them in achieving their objectives. Axolabs facility in Petaluma is focused on manufacturing scale-up and production to cGMP of multigram to kilograms of API for pre-clinical and clinical development. Our site in California has been involved in oligonucleotide synthesis for three decades and established the therapeutics activity in 2019. With around 70 staff and two manufacturing trains, Axolabs offers a flexible manufacturing service out of Petaluma that draws where necessary on our industry and chemical and analytical expertise in Kulmbach.

SHIFT HOURS

Monday to Thursday, 4:00 pm to 2:00 AM PST. Job DescriptionPosition SummaryThe Lead Technician is responsible for executing production processes for therapeutic oligonucleotides in a cGMP-compliant facility. This role supports the manufacturing of high-quality nucleic acid-based therapeutics through hands-on operation of equipment, adherence to standard operating procedures (SOPs), and meticulous documentation practices. The lead technician works closely with cross-functional teams including Quality Assurance, Process Development, and Manufacturing Sciences and technology to ensure consistent, safe, and efficient production.

To perform this job successfully, an individual must be able to perform each of the following essential functions satisfactorily.

Roles and ResponsibilitiesOligonucleotide ProductionLead routine and non-routine operations under cGMP conditions: synthesis, cleavage and deprotection, purification, ultrafiltration and diafiltration, lyophilization, and other required chemical reactions.

Support activities related to production such as lab sanitization, material movement, and safety checks.

Equipment OperationOperate and maintain small and large scale equipment including synthesizers, chromatography systems, and lyophilizes.

Perform instrument calibrations, preventative maintenance, and validations.

Oversee equipment readiness in alignment with scheduled production.cGMP ComplianceDemonstrate GDP in production records, logbooks, and other required documents.

Oversee team compliance with internal standard operating procedures to ensure regulatory adherence to cGMP requirements.

Lead Quality investigations, CAPA implementations, and audit readiness.

Continuous ImprovementLead in troubleshooting activities related to production.

Identify and execute improvement initiatives.

Provide feedback and review of systems related to operations.

Train and mentor new team members.

Cross-Functional CollaborationRepresent manufacturing in large and complex multi-department projects.

QualificationsMinimum Qualifications:

Associate's or Bachelor's degree in Biotechnology, Chemistry, or related field

• OR•3 years of experience in a cGMP chemical manufacturing role preferably oligonucleotide related.

Preferred Qualifications:

Experience with mid to large laboratory equipment and operations.

Experience operating within cGMP quality systemsCompetencies &

Behaviours:

Strong interpersonal and communication skillsAble to work in a fast paced and dynamic environmentDetail orientedAble to identify, assess, and address problems efficientlyAdditional InformationWhat we offer (US based-employees):

Competitive compensation with strong bonus programComprehensive medical, dental, and vision benefits for employees and dependentsFSA/HSA Pre-tax savings plans for health care, childcare, and elder careDeductible Buffer Insurance and Critical Illness Insurance401(k) retirement plan with matching employer contributionCompany-paid short

• and long
• term disability, life insurance, and employee assistance programFlexible work options
• 8, 10 and 12 hour shifts available with option of day, swing and night shifts.

Pet Insurance for our furry friendsEnhanced Parental leave of 8 additional weeksPTO that begins immediatelyFull week paid off during the holidaysTown Hall monthly meeting onsite/virtual, Cheer program where employees are recognized for outstanding work, Companywide social events, frequent catered lunches and much more!

The typical pay range for this role is:

Minimum:

$24.87

Maximum:

 $41.46This range represents the low and high end of the anticipated salary range for the California

• based position.

The actual base salary will depend on several factors such as: experience, skills, and location.

ABOUT LGC

 LGC is a leading, global life science tools company, providing mission-critical components and solutions into high-growth application areas across the human healthcare and applied market segments. Its high-quality product portfolio is comprised of mission-critical tools for genomic analysis and for quality assurance applications, which are typically embedded and recurring within our customers' products and workflows and are valued for their performance, quality, and range. 

OUR VALUESPASSIONCURIOSITY

 INTEGRITYBRILLIANCERESPECTEQUAL

OPPORTUNITIES

 LGC strongly believes that every job applicant and employee should be valued for their individual talents regardless of age, disability, race, color, ethnic or national origin, sex, sexual orientation, gender reassignment, marital or civil partnership, pregnancy or maternity, religion, or belief. Short listing, interviewing and selection will always be carried out without regard to gender, sexual orientation, marital status, color, race, nationality, ethnic or national origins, religion or belief, age, or trade union membership.

For more information about LGC, please visit our website www.lgcgroup.com#scienceforasaferworld