Senior Director, QualitySouth San Francisco, CA

Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success. Coaches others on resource management and work distribution/delegation. Aligns work to Maze's strategy, mission, and vision. Develop Others and Self Develops staff capabilities to handle delegation of responsibilities. Encourages staff to develop and execute personal stretch goals. Identifies and recommends ways to increase inclusive leadership. What We're Looking For Bachelor's degree in a scientific discipline with 12+ years of progressive experience in biotech or pharma GxP quality assurance and compliance Deep knowledge of global GxP regulations, including U.S. CFR, EMA, ICH, and other relevant standards Proven experience in building and refining QA related systems that support clinical and commercial development Strong understanding of GMP Quality across raw materials, drug substance, drug product, labeling, packaging, and distribution, including testing, stability, and retention Strong understanding of GCP Quality, including CRO oversight, clinical trial conduct, and inspection readiness Experience enabling release of investigational and commercial materials in compliance with regulatory requirements Skilled in GxP training and implementation, with a focus on practical adoption Track record of leading and supporting regulatory inspections, including FDA, EMA, and global agencies Experience drafting audit responses and implementing CAPAs Proficiency in root cause analysis and CAPA management Familiarity with eQMS and eTMF systems Experience managing and developing direct reports, with a focus on mentorship and professional growth Collaborative mindset, with experience working across internal teams and external partners Strong strategic and organizational skills, with the ability to prioritize multiple projects Excellent leadership and communication skills (written and oral) High ethical standards with a positive, proactive, and solution-oriented approach Willingness to travel domestically and internationally for inspections, vendor oversight, and industry events This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week About Maze Therapeutics Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company's pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco. Our People Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. Our Core Values Further Together

• Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission. Impact Obsessed
• We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. Stand True
• Our integrity is foundational; it guides us no matter the obstacle. The expected annual salary range for employees located in the San Francisco Bay Area is $257,000
• $314,000.

Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future. Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. #LI-Hybrid Company About Maze Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. We are advancing a pipeline using our Compass platform, which allows us to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process we refer to as variant functionalization. Our Compass platform has been purpose-built to inform all phases of our drug discovery and development process through clinical trial design. We are currently advancing two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease, or CKD. Our goal is to bring novel precision medicines to patients with common diseases, which is where we believe we can maximize our impact on human health. Our People Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. Our Core Values Further Together

• Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission. Impact Obsessed
• We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. Stand True
• Our integrity is foundational; it guides us no matter the obstacle.

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