Postdoctoral Fellow in Santagata Lab (Harvard Program in Therapeutic Science) - Methods/Platform and Spatial Biology

Position Details Title Postdoctoral Fellow in Santagata Lab (Harvard Program in Therapeutic Science) - Methods/Platform and Spatial Biology School Harvard Medical School Department/Area Harvard Program in Therapeutic Science Position Description We invite applicants for a postdoctoral fellow position inthe Santagata lab at Harvard Medical School in Boston Massachusetts. The work of the lab focuses on developing and applying multiplexed imaging, spatial multi-omics, and computational pathology approaches to understand how microenvironmental signals shape cell states in human disease, particularly cancer. We welcome applications from recent PhD graduates and post-doctoral fellows who are interested in these or related fields, particularly those who may bring strong quantitative, computational, or physical science perspectives. Candidates with backgrounds in physics, applied mathematics, or computational sciences who are motivated to work at the interface of biology and medicine are especially encouraged to apply. The successful candidate will work with Dr. Santagata to develop an independent research program aligned with the lab's focus on spatial biology and clinically relevant diagnostics. Current projects include understanding how metabolic gradients and chromatin states encode spatial information in tumors. In parallel, the lab is integrating advanced multiplexed imaging with computational pathology and quantitative morphology to define image-based biomarkers of tumor biology and therapeutic resistance. These efforts combine spatial profiling, pathology-informed feature extraction, and systems-level analysis to link molecular states with tissue architecture, enabling the development of interpretable, clinically relevant diagnostic and predictive frameworks. In addition to carrying out research, the successful candidate will be expected to apply for fellowship funding, contribute to the grant and manuscript writing, participate in mentoring and teaching within the lab, and contribute to a collaborative and interdisciplinary research environment. Salary and Benefits This position is salaried and benefits eligible. Information regarding postdoctoral fellow salary, which is determined by the number of years post PhD, and benefits can be found at https://postdoc.hms.harvard.edu/guidelines. With this appointment, you are represented by the Harvard Academic Workers (HAW) - UAW for purposes of collective bargaining and matters affecting your compensation and working conditions. Basic Qualifications Ph.D. or M.D./Ph.D. in computational biology, systems biology, physics, applied mathematics, bioengineering, or related fields quantitative disciplines. Strong programming and computational skills (e.g., Python, C++, or similar), and experience with modeling, data analysis, or large-scale datasets Interest in transitioning quantitative approaches into biological or clinical research contexts Additional Qualifications Special Instructions Required documents: Curriculum Vitae Statement of Research for PhD work Cover Letter describing your interest in the lab and initial ideas for new research directions or projects you could undertake in the lab. Note with names and contact information for three people who have agreed to serve as your reference Please submit application documents through the ARIeS portal. Applications will be considered beginning May 14, 2026. Selected candidates will be invited for in-person interviews involving a research presentation on past work. Expected Dates Application deadline: May 30, 2026 Start date: The position is expected to start on or around September 1, 2026 with some flexibility.

Duration:

This is a one-year term position from the date of hire, with the possibility of extension, contingent upon work performance, business need, and continued funding to support the position. Contact Information Tyson Schrader, Administrative Manager 200 Longwood Ave, ARM 109 Boston, MA 02115 Contact Email hits_hr@hms.harvard.edu Salary Range This position is salaried and benefits eligible. Information regarding postdoctoral fellow salary, which is determined by the number of years post PhD, and benefits can be found at https://postdoc.hms.harvard.edu/guidelines. Minimum Number of References Required 3 Maximum Number of References Allowed Keywords EEO/Non-Discrimination Commitment Statement Harvard University is committed to equal opportunity and non-discrimination. We seek talent from all parts of society and the world, and we strive to ensure everyone at Harvard thrives. Our differences help our community advance Harvard's academic purposes. Harvard has an equal employment opportunity policy that outlines our commitment to prohibiting discrimination on the basis of race, ethnicity, color, national origin, sex, sexual orientation, gender identity, veteran status, religion, disability, or any other characteristic protected by law or identified in the university's non-discrimination policy. Harvard's equal employment opportunity policy and non-discrimination policy help all community members participate fully in work and campus life free from harassment and discrimination. Supplemental Questions Required fields are indicated with an asterisk (•). Applicant Documents Required Documents Curriculum Vitae Cover Letter Statement of Research Note Optional Documents Publication