ABOUT US

Scripps Research is a nonprofit biomedical institute ranked as one of the most influential in the world for its impact on innovation. We celebrated our 100-year legacy in 2024. This significant milestone marks a century of seminal discoveries in immunology, infectious diseases (such as COVID-19, flu, HIV), neuroscience, heart disease, cancer, and more. Located in La Jolla, California, the institute houses six research departments, multiple Nobel laureates, a top-ranked graduate school and a leading postdoctoral training program. Scripps Research encompasses two elite and highly innovative institutes, the Calibr-Skaggs Institute for Innovative Medicines and Scripps Research Translational Institute, which merge foundational studies in biology, chemistry and computer science with translational science to produce pioneering drugs and advances in digital and precision medicine. Together, we cultivate new scientific leaders and expand the frontiers of knowledge to deliver medical breakthroughs impacting human health around the globe. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

POSITION TITLE

Postdoctoral Associate

POSITION SUMMARY

The Jardine Lab at Scripps Research is an interdisciplinary research group that applies engineering-based approaches to understand challenging biological problems and develop therapeutic interventions. We are currently seeking applications for a postdoctoral position focused on developing medical countermeasures against botulism neurotoxin intoxication. The selected candidate will design, construct and screen synthetic monobody-based libraries to identify high affinity binders that broadly neutralize botulinum neurotoxins (BoNT). This project will be done in collaboration with Calibr, the translational division at Scripps Research focused on therapeutic development.

KEY RESPONSIBILITIES

Design, construct, and validate yeast display monobody (Mb) libraries. Conduct discovery campaigns against BoNTs to identify broadly neutralizing Mb candidates. Produce and characterize Mbs identified through discovery campaigns. Measure binding affinity and specificity Evaluate the biochemical and biophysical properties of lead candidates, including polyreactivity, size exclusion chromatography profiles and thermal stability. Establish, optimize, and perform previously described functional assays for BoNT neutralization. Affinity mature lead Mb candidates to improve potency and breadth across diverse BoNT variants. Analyze and interpret experimental data, using creative, solution-oriented approaches to overcome technical challenges. Prepare manuscripts for publication and present research findings at major scientific conferences. Measure binding affinity and specificity Evaluate the biochemical and biophysical properties of lead candidates, including polyreactivity, size exclusion chromatography profiles and thermal stability. Establish, optimize, and perform previously described functional assays for BoNT neutralization. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges. Scripps Research adheres to the National Institutes of Health (\"NIH\") and National Science Foundation (\"NSF\") definition of a

Postdoctoral Scholar :

An individual who has received a doctoral degree (or equivalent) and is engaged in a temporary and defined period of mentored, advanced training to enhance the professional skills and research independence needed to pursue their chosen career path. Make Scripps Research your next step to advance and develop your career. Click here to learn more about our

Postdoctoral Program and Services:

https://education.scripps.edu/postdoctoral/

REQUIREMENTS/QUALIFICATIONS :

PhD in a relevant scientific field, with a strong record of research productivity and publication. Excellent analytical and problem solving skills. Strong written and oral communication skills, including experience preparing reports and manuscripts and delivering scientific presentations. Ability to work both independently and collaboratively in a dynamic, interdisciplinary research environment. Strong interpersonal skills, with demonstrated cultural awareness and respect for colleagues from diverse backgrounds.

COMPENSATION

: Postdoctoral Associates will be hired following the National Institute of Health and California's exempt salary guidelines, which provide for a starting range of $70,304- $75,353. Consideration will be given to experience that exceeds the listed requirements.

COMPREHENSIVE BENEFITS INCLUDE

Eligibility for retirement plans with employer contribution. Full suite of Health and Welfare plans including four medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more. Access to Dependent Flexible Spending Accounts Free on-site Counseling Center which provides confidential counseling services to benefits-eligible employees Paid Time Off - 5 days annually Free, on-site parking. Pet Insurance The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.

EEO Statement:

The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. 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POSTDOCTORAL ASSOCIATE - JARDINE LAB - Immunology and Microbiology