Design and synthesis of inhibitors of α-Synuclein aggregation and α-Synuclein-lipid interaction // Design and synthesis of inhibitors of α-Synuclein aggregation and α-Synuclein-lipid interaction

8 Apr 2026 Job Information Organisation/Company Université Paris-Saclay GS Santé et médicaments Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 4 May 2026•22:00 (UTC) Country France Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description The goal of this project is to design and synthesize peptides and peptidomimetics capable of inhibiting the aggregation of α-Synuclein and α-Synuclein binding to lipids. Molecular simulations will be performed to prove the mode of action of the best-performing inhibitors and to design improved inhibitors. In particular, the DC enrolled in this position, will synthesize peptide mimics to modulate the pathological α-Synuclein protein aggregation as well as α-Synuclein/lipids interaction. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non natural amino acids and of peptide mimics, designed according to the results of the structural biology results of the consortium. He/She will also perform conformational studies using NMR techniques, and will be involved in some biophysical and biochemical evaluations of the activity and the interaction of the prepared compounds with α-Synuclein or with lipids.•The goal of this project is to design and synthesize peptides and peptidomimetics capable of inhibiting the aggregation of α-Synuclein and α-Synuclein binding to lipids. Molecular simulations will be performed to prove the mode of action of the best-performing inhibitors and to design improved inhibitors. In particular, the DC enrolled in this position, will synthesize peptide mimics to modulate the pathological α-Synuclein protein aggregation as well as α-Synuclein/lipids interaction. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non natural amino acids and of peptide mimics, designed according to the results of the structural biology results of the consortium. He/She will also perform conformational studies using NMR techniques, and will be involved in some biophysical and biochemical evaluations of the activity and the interaction of the prepared compounds with α-Synuclein or with lipids.•Début de la thèse : 01/09/2026

WEB :

https://lipagg.

eu/ Funding category:

Europe•MSCA (Marie Sklodowska-Curie Action) Where to apply Website https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/137854 Requirements Specific Requirements The ideal candidate for this position is a highly motivated and talented researcher holding a Master's degree (MSc or equivalent) in organic or medicinal chemistry. A solid background or keen interest in molecular simulations is highly desirable. The ideal candidate should be enthusiastic about tackling new scientific challenges and demonstrate strong motivation, persistence, and a results-oriented mindset. The candidate should be able to work effectively both independently and as part of an interdisciplinary team. Excellent oral and written communication skills in English are essential. Strong organisational and planning abilities are also required. This position is subject to the mobility and eligibility rules of the Marie Skłodowska-Curie Actions. In particular, the candidate must not have resided or carried out their main activity (work, studies, etc.) in France for more than twelve months during the three years immediately prior to the recruitment date, unless as part of a procedure for obtaining refugee status under the Geneva Convention. At the date of recruitment, the candidate must be a Doctoral Candidate, i.e. in the first five years (full-time equivalent research experience) of their research career and must not have been awarded a doctoral degree.

The ideal candidate for this position is a highly motivated and talented researcher holding a Master's degree (MSc or equivalent) in organic or medicinal chemistry. A solid background or keen interest in molecular simulations is highly desirable. The ideal candidate should be enthusiastic about tackling new scientific challenges and demonstrate strong motivation, persistence, and a results-oriented mindset. The candidate should be able to work effectively both independently and as part of an interdisciplinary team. Excellent oral and written communication skills in English are essential. Strong organisational and planning abilities are also required. This position is subject to the mobility and eligibility rules of the Marie Skłodowska-Curie Actions. In particular, the candidate must not have resided or carried out their main activity (work, studies, etc.) in France for more than twelve months during the three years immediately prior to the recruitment date, unless as part of a procedure for obtaining refugee status under the Geneva Convention. At the date of recruitment, the candidate must be a Doctoral Candidate, i.e. in the first five years (full-time equivalent research experience) of their research career and must not have been awarded a doctoral degree. Additional Information Work Location(s) Number of offers available 1 Company/Institute Université Paris-Saclay GS Santé et médicaments

Country France City Orsay Geofield STATUS:

EXPIRED