Design and synthesis of inhibitors of Aβ and IAPP aggregation and Aβ-lipid and IAPP-lipid complexes // Design and synthesis of inhibitors of Aβ and IAPP aggregation and Aβ-lipid and IAPP-lipid complexes

8 Apr 2026 Job Information Organisation/Company Université Paris-Saclay GS Santé et médicaments Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 4 May 2026•22:00 (UTC) Country France Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description The goal of this project is to design and synthesize peptides and peptidomimetics targeting the binding hotspot between Aβ/IAPP and lipids as inhibitors of Aβ-lipid and IAPP-lipid interaction. The activity of the inhibitors will be studied using various biophysical technics. The selected PhD candidate will participate in the EU-funded

HORIZON-MSCA-DN-2024-01

project LipAgg. The LipAgg network brings together partners from five European countries and comprises nine academic institutions and twelve industrial partners. The consortium is committed to delivering an outstanding training programme for fifteen Doctoral Candidates (DCs) aimed at elucidating the role of lipids in the toxicity and propagation of protein aggregation. The Doctoral candidate key tasks will be to manage and carry out the assigned research project, participate in the LipAgg training and network activities, take PhD courses, write scientific articles and the PhD thesis, participate in national and international congresses and scientific meetings, undertake a research stay at an external research laboratory within the LipAgg network, and disseminate the obtained scientific results. In particular, the DC enrolled in this position, will synthesize peptide mimics to modulate the pathological Aβ-lipid and IAPP-lipid interaction. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non natural AAs and of peptide mimics, designed according to the results of the structural biology results of the consortium. He/She will also perform conformational studies using NMR techniques, and will be involved in some biophysical and biochemical evaluations of the activity and of the influence of the prepared compounds on Aβ/lipid effects. The Doctoral Candidate will be enrolled at University of Paris-Saclay under the supervision of Prof. Sandrine Ongeri, for the design and the synthesis of the peptides and peptidomimetics (24 months). The project includes a 9-month secondment at the Università degli Studi di Catania (Italy) to perform Biochemical and biophysical evaluations under the supervision of Prof. Carmelo La Rosa, as well as a 3-month secondment in Polypeptide Company to develop green peptide synthesis (Strasbourg, France).•The goal of this project is to design and synthesize peptides and peptidomimetics targeting the binding hotspot between Aβ/IAPP and lipids as inhibitors of Aβ-lipid and IAPP-lipid interaction. The activity of the inhibitors will be studied using various biophysical technics. The selected PhD candidate will participate in the EU-funded

HORIZON-MSCA-DN-2024-01

project LipAgg. The LipAgg network brings together partners from five European countries and comprises nine academic institutions and twelve industrial partners. The consortium is committed to delivering an outstanding training programme for fifteen Doctoral Candidates (DCs) aimed at elucidating the role of lipids in the toxicity and propagation of protein aggregation. The Doctoral candidate key tasks will be to manage and carry out the assigned research project, participate in the LipAgg training and network activities, take PhD courses, write scientific articles and the PhD thesis, participate in national and international congresses and scientific meetings, undertake a research stay at an external research laboratory within the LipAgg network, and disseminate the obtained scientific results. In particular, the DC enrolled in this position, will synthesize peptide mimics to modulate the pathological Aβ-lipid and IAPP-lipid interaction. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non natural AAs and of peptide mimics, designed according to the results of the structural biology results of the consortium. He/She will also perform conformational studies using NMR techniques, and will be involved in some biophysical and biochemical evaluations of the activity and of the influence of the prepared compounds on Aβ/lipid effects. The Doctoral Candidate will be enrolled at University of Paris-Saclay under the supervision of Prof. Sandrine Ongeri, for the design and the synthesis of the peptides and peptidomimetics (24 months). The project includes a 9-month secondment at the Università degli Studi di Catania (Italy) to perform Biochemical and biophysical evaluations under the supervision of Prof. Carmelo La Rosa, as well as a 3-month secondment in Polypeptide Company to develop green peptide synthesis (Strasbourg, France).•Début de la thèse : 01/09/2026

WEB :

https://lipagg.

eu/ Funding category:

Europe•MSCA (Marie Sklodowska-Curie Action) Where to apply Website https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/137855 Requirements Specific Requirements The ideal candidate for this position is a highly motivated and talented researcher holding a Master's degree (MSc or equivalent) in organic or medicinal chemistry. A solid background or keen interest in biochemistry and biophysics is highly desirable. The ideal candidate should be enthusiastic about tackling new scientific challenges and demonstrate strong motivation, persistence, and a results-oriented mindset. The candidate should be able to work effectively both independently and as part of an interdisciplinary team. Excellent oral and written communication skills in English are essential. Strong organisational and planning abilities are also required. This position is subject to the mobility and eligibility rules of the Marie Skłodowska-Curie Actions. In particular, the candidate must not have resided or carried out their main activity (work, studies, etc.) in France for more than twelve months during the three years immediately prior to the recruitment date, unless as part of a procedure for obtaining refugee status under the Geneva Convention. At the date of recruitment, the candidate must be a Doctoral Candidate, i.e. in the first five years (full-time equivalent research experience) of their research career and must not have been awarded a doctoral degree.

The ideal candidate for this position is a highly motivated and talented researcher holding a Master's degree (MSc or equivalent) in organic or medicinal chemistry. A solid background or keen interest in biochemistry and biophysics is highly desirable. The ideal candidate should be enthusiastic about tackling new scientific challenges and demonstrate strong motivation, persistence, and a results-oriented mindset. The candidate should be able to work effectively both independently and as part of an interdisciplinary team. Excellent oral and written communication skills in English are essential. Strong organisational and planning abilities are also required. This position is subject to the mobility and eligibility rules of the Marie Skłodowska-Curie Actions. In particular, the candidate must not have resided or carried out their main activity (work, studies, etc.) in France for more than twelve months during the three years immediately prior to the recruitment date, unless as part of a procedure for obtaining refugee status under the Geneva Convention. At the date of recruitment, the candidate must be a Doctoral Candidate, i.e. in the first five years (full-time equivalent research experience) of their research career and must not have been awarded a doctoral degree. Additional Information Work Location(s) Number of offers available 1 Company/Institute Université Paris-Saclay GS Santé et médicaments

Country France City Orsay Geofield STATUS:

EXPIRED