Associate Engineer, RNA Starting Material MS&T

Associate Engineer, RNA Starting Material MS&T Sarepta Therapeutics United States, Massachusetts, Andover May 16, 2026 Why Sarepta? Why Now? The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. What Sarepta Offers At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas: Physical and Emotional Wellness Financial Wellness Support for Caregivers For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us The Importance of the Role The Associate Engineer, RNA Starting Material MS&T will work in a team focused on lab-scale organic synthesis, purification, analysis, and characterization of the nucleoside-based and lipid building blocks of Sarepta's phosphorodiamidate morpholino oligomers (PMOs), next-generation PMO, and siRNA platforms. The role will involve both synthesis of reference markers/standards and participating in supervised RNA starting materials manufacturing process chemistry development and scale-up projects to optimize and troubleshoot syntheses. The role will involve cross-functional training, regular interaction with Analytical/QC resources, and interpretation of HPLC, GC, KF, and NMR data. The position involves protocol and report writing and requires excellent organic chemistry and problem-solving skills. The Opportunity to Make a Difference Support commercial supply assurance for RNA starting materials by synthesizing nucleoside reference markers/standards.
Execute development studies either independently or as part of a team under supervision.
Assess scalability of proposed changes and execute experiments to mimic the impacts of operations at large scale.
Participate in the Technology Transfer of improved processes to manufacturing sites.
Cultivate a firm scientific understanding of Sarepta's manufacturing processes to support process improvements, troubleshooting, and technology transfers.
Perform synthesis and purification (chromatography) of nucleoside analogs to support both production and development goals.
Contribute to collaborative efforts to characterize and manage the impurity profiles of intermediates.
Use scientific judgement to determine likely source and fate of newly identified impurities and design experiments to test hypotheses as part of a cross-functional team.
Data compilation, data interpretation, documentation of study results, and presentation of data and conclusions.
Participate in vendor update meetings and provide input on ongoing vendor production projects. More about You B.S. (required) in Chemical Engineering, Chemistry, or related discipline, 0-2 years related experience
Technical competence in organic chemistry and familiarity with analyzing and interpreting data from GC, LC-MS, HPLC, NMR, and KF instrumentation. Experience running HPLC methods is strongly preferred.
Able to handle multi-task workload and perform effectively under deadlines
Effective written and verbal communication skills
Strong interpersonal skills and attention to detail are necessary
May require